How cognition modulates affective responses to taste and flavor: Top-down influences on the orbitofrontal and pregenual cingulate cortices
How cognition modulates affective responses to taste and flavor: Top-down influences on the orbitofrontal and pregenual cingulate cortices
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DOI：
10.1093/cercor/bhm185
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发表时间：
2008-07-01
期刊：
影响因子：
3.7
通讯作者：
Bilderbeck, Amy
中科院分区：
文献类型：
--
作者：
Grabenhorst, Fabian;Rolls, Edmund T.;Bilderbeck, Amy
认知如何影响大脑对食物味道和味道的情感表征不仅对了解大脑自上而下的影响很重要，而且与食欲控制和肥胖等热门问题有关。我们使用功能磁共振成像发现，眼眶前额叶皮质中与umami味道和味道的情感价值相关的激活(通过与愉悦程度评级的相关性显示)受到词级描述符的调制。与味觉有关的情感激活是在一个接受眶前叶皮质(前扣带回皮质)的区域进行调节的，而在另一个接受眶前叶皮质(腹侧纹状体)的区域则调节了味觉和味道。在岛状味觉皮质中没有发现与情感相关的认知调节，那里代表了味道的强烈而不是愉悦。我们的结论是，自上而下的语言水平的认知效应远远延伸到代表味觉和味道的食欲价值的最早的皮质区域。这是认知影响控制食欲的神经机制的重要方式。
How cognition influences the affective brain representations of the taste and flavor of a food is important not only for understanding top-down influences in the brain, but also in relation to the topical issues of appetite control and obesity. We found using functional magnetic resonance imaging that activations related to the affective value of umami taste and flavor (as shown by correlations with pleasantness ratings) in the orbitofrontal cortex were modulated by word-level descriptors. Affect-related activations to taste were modulated in a region that receives from the orbitofrontal cortex, the pregenual cingulate cortex, and to taste and flavor in another region that receives from the orbitofrontal cortex, the ventral striatum. Affect-related cognitive modulations were not found in the insular taste cortex, where the intensity but not the pleasantness of the taste was represented. We conclude that top-down language-level cognitive effects reach far down into the earliest cortical areas that represent the appetitive value of taste and flavor. This is an important way in which cognition influences the neural mechanisms that control appetite.