Bistability of cerebellar Purkinje cells modulated by sensory stimulation
Bistability of cerebellar Purkinje cells modulated by sensory stimulation
复制标题
DOI：
10.1038/nn1393
复制
发表时间：
2005-02-01
影响因子：
25
通讯作者：
Häusser, MH
中科院分区：
文献类型：
--
作者：
Loewenstein, Y;Mahon, S;Häusser, MH
短暂刺激后神经元活动的持续变化是许多神经元微电路的共同特征。这种持续的活动可以通过持续的混响网络活动或单个细胞的内在生物物理特性来维持。在这里，我们证明，大鼠和豚鼠小脑浦肯野细胞在体内表现出双稳态的膜电位和尖峰输出的时间尺度上的秒。膜电位状态之间的转换可以由相同的短暂电流脉冲双向触发。我们还表明，感觉激活的攀爬纤维输入可以切换浦肯野细胞之间的两种状态。浦肯野细胞双稳态的内在本质及其通过感觉输入的控制可以用一个简单的生物物理模型来解释。浦肯野细胞的双稳态性可能在小脑皮层感觉信息的短期加工和储存中起关键作用。
A persistent change in neuronal activity after brief stimuli is a common feature of many neuronal microcircuits. This persistent activity can be sustained by ongoing reverberant network activity or by the intrinsic biophysical properties of individual cells. Here we demonstrate that rat and guinea pig cerebellar Purkinje cells in vivo show bistability of membrane potential and spike output on the time scale of seconds. The transition between membrane potential states can be bidirectionally triggered by the same brief current pulses. We also show that sensory activation of the climbing fiber input can switch Purkinje cells between the two states. The intrinsic nature of Purkinje cell bistability and its control by sensory input can be explained by a simple biophysical model. Purkinje cell bistability may have a key role in the short-term processing and storage of sensory information in the cerebellar cortex.