Sex differences in stress effects on response and spatial memory formation
Sex differences in stress effects on response and spatial memory formation
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DOI：
10.1016/j.nlm.2013.11.020
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发表时间：
2014-03-01
影响因子：
2.7
通讯作者：
Schwabe, Lars
中科院分区：
文献类型：
--
作者：
Guenzel, Friederike M.;Wolf, Oliver T.;Schwabe, Lars
众所周知，压力和压力荷尔蒙会影响学习和记忆过程。然而，尽管应激对海马区依赖的陈述性学习和记忆的影响已经得到了充分的研究，但应激对纹状体依赖的刺激反应(S-R)学习和记忆的影响却相对较少受到关注。最近的证据表明，学习后不久糖皮质激素应激激素能促进S-R记忆的巩固，而在保持测试之前的应激会损害S-R记忆的提取。目前尚不清楚压力是否也会影响人类对S-R记忆的获得。为此，我们研究了急性应激对S-R记忆形成的影响，并将这些应激效应与海马区依赖的空间记忆的应激效应进行了对比。健康男性和女性在完成一项S-R任务和两项空间学习任务之前，接受了应激源(社会评价冷加压试验)或对照操作。一周后对记忆进行评估。我们的数据显示，压力会损害男性的S-R记忆能力，但对女性没有影响。相反，女性的空间记忆会因压力而受损，而男性则不会。这些发现进一步证明，压力可能会改变海马体以外的学习和记忆过程。此外，我们的数据强调，参与者的性别可能在压力对多个记忆系统的影响中发挥关键作用。(C)2013 Elsevier Inc.保留所有权利。
Stress and stress hormones are known to affect learning and memory processes. However, although effects of stress on hippocampus-dependent declarative learning and memory are well-documented, relatively little attention has been paid to the impact of stress on striatum-dependent stimulus-response (S-R) learning and memory. Recent evidence indicates that glucocorticoid stress hormones shortly after learning enhance S-R memory consolidation, whereas stress prior to retention testing impairs S-R memory retrieval. Whether stress affects also the acquisition of S-R memories in humans remains unclear. For this reason, we examined here the effects of acute stress on S-R memory formation and contrasted these stress effects with those on hippocampus-dependent spatial memory. Healthy men and women underwent a stressor (socially evaluated cold pressor test, SECPT) or a control manipulation before they completed an S-R task and two spatial learning tasks. Memory was assessed one week later. Our data showed that stress impaired S-R memory performance in men but not in women. Conversely, spatial memory was impaired by stress in women but not in men. These findings provide further evidence that stress may alter learning and memory processes beyond the hippocampus. Moreover, our data underline that participants' sex may play a critical role in the impact of stress on multiple memory systems. (C) 2013 Elsevier Inc. All rights reserved.