Baseline correction of phase-contrast images in congenital cardiovascular magnetic resonance.
Baseline correction of phase-contrast images in congenital cardiovascular magnetic resonance.
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DOI：
10.1186/1532-429x-12-11
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发表时间：
2010-03-05
期刊：
影响因子：
--
通讯作者：
Lai WW
中科院分区：
文献类型：
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作者：
Holland BJ;Printz BF;Lai WW
相位对比（PC）先天性CMR流量测量中的一个潜在误差源是由局部非补偿涡电流引起的相位偏移引起的。这些相位偏移误差的体模校正已被证明可以更准确地测量心脏结构正常的成年人的血流。我们报告了在临床先天性CMR计划中，体模校正对PC流量测量的影响。根据临床指征测量升主动脉、主肺动脉和左右肺动脉的血流，并从这些测量结果中得出其他值，如Qp/Qs。在我们的研究人群中，149例患者的体模校正导致已知或疑似心脏病患者的13%至48%的这些相位对比测量值发生临床显著变化。总体而言，分析了640个测量值或计算值，在31%中发现了具有临床意义的变化。较大的血管与较大的相位偏移误差相关，22%的PC流量测量变化归因于测量的血管尺寸。在心脏结构正常的患者中，体模校正后的肺-体循环流量比体模校正前更接近1.0。法乐四联症患者的体模矫正效果与整体相比无显著差异。在已知或疑似先天性心脏病患者中，体模校正通常导致PC血流测量值发生临床显著变化。在进行临床CMR的实验室中，如果怀疑存在显著的相位偏移误差，则应考虑常规使用体模校正进行PC流量测量。
One potential source of error in phase contrast (PC) congenital CMR flow measurements is caused by phase offsets due to local non-compensated eddy currents. Phantom correction of these phase offset errors has been shown to result in more accurate measurements of blood flow in adults with structurally normal hearts. We report the effect of phantom correction on PC flow measurements at a clinical congenital CMR program. Flow was measured in the ascending aorta, main pulmonary artery, and right and left pulmonary arteries as clinically indicated, and additional values such as Qp/Qs were derived from these measurements. Phantom correction in our study population of 149 patients resulted in clinically significant changes in 13% to 48% of these phase-contrast measurements in patients with known or suspected heart disease. Overall, 640 measurements or calculated values were analyzed, and clinically significant changes were found in 31%. Larger vessels were associated with greater phase offset errors, with 22% of the changes in PC flow measurements attributed to the size of the vessel measured. In patients with structurally normal hearts, the pulmonary-to-systemic flow ratio after phantom correction was closer to 1.0 than before phantom correction. There was no significant difference in the effect of phantom correction for patients with tetralogy of Fallot as compared to the group as a whole. Phantom correction often resulted in clinically significant changes in PC blood flow measurements in patients with known or suspected congenital heart disease. In laboratories performing clinical CMR with suspected phase offset errors of significance, the routine use of phantom correction for PC flow measurements should be considered.