Objective measures of gait and balance in healthy non-falling adults as a function of age.
Objective measures of gait and balance in healthy non-falling adults as a function of age.
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作为年龄函数的健康非跌倒成年人的步态和平衡的客观测量。
DOI：
10.1016/j.gaitpost.2018.07.167
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发表时间：
2018
期刊：
影响因子：
2.4
通讯作者：
Larson-Prior,Linda
中科院分区：
文献类型：
--
作者：
Virmani,Tuhin;Gupta,Harsh;Shah,Jesal;Larson-Prior,Linda
研究背景神经退行性疾病的发病率随着年龄的增长而增加。先前使用不同人群和步态范例的研究报告了各种参数随年龄变化，其中一些与福尔斯和死亡率相关。在这里，我们使用三种不同的范式来评估步态和平衡在健康nonfallers.Research QuestionWhat客观步态和平衡参数与aging.MethodsHealthy年龄在21-79岁的受试者年龄没有历史的福尔斯，下肢矫形手术或慢性疼痛。受试者在20 × 4英尺压力传感器垫（Zeno Walkway，Protokinetics，哈弗敦，PA）上行走，采用三种不同的步态模式，（i）稳态步态，（ii）在手机上发短信时执行双重任务，（iii）串联步态。收集数据并使用PKMAS软件（Protokinetics）进行分析。使用SPSS 24（IBM）进行线性回归分析，逐步多变量分析，和分组分析的步态参数。分组分析和线性回归分析表明，所测参数具有不同的显著性。对三种不同步态模式评估的所有31个参数进行逐步多变量分析，显示年龄与（i）步幅-步幅变异性（i）脚步的综合压力和（ii）稳态步态期间的步长，（iii）双任务时的平均步长和（iv）串联步态时的平均步长之间存在微弱但显著的相关性（R2= 0.382，t = 2.26，p = 0.026）。显著性在没有影响步态的福尔斯或医学疾病病史的健康受试者群体中，在稳态步态和平衡的客观测量中存在微弱但显著的年龄相关变化。未来的前瞻性纵向数据将有助于预测这与老年人福尔斯跌倒的相关性。
BackgroundNeurodegenerative diseases increase in incidence with age. Prior studies using differing populations and gait paradigms have reported various parameters changing with age, some of which correlate with falls and mortality. Here we use three different paradigms to evaluate gait and balance in healthy non-fallers.Research questionWhat objective gait and balance parameters are correlated with aging.MethodsHealthy subjects aged 21–79 years without histories of falls, lower extremity orthopedic procedures or chronic pain were included. Subjects walked on a 20 × 4 foot pressure sensor mat (Zeno Walkway, Protokinetics, Havertown, PA) under three different gait paradigms, (i) steady-state gait, (ii) dual-task while texting on a cellular phone and (iii) tandem gait. Data was collected and analyzed using PKMAS software (Protokinetics). Linear regression analysis, stepwise multivariate analysis, and grouped analysis of gait parameters was performed using SPSS 24 (IBM).ResultsSeventy-five subjects were enrolled. Grouped analysis and linear regression analysis showed differing significance in parameters tested. Step-wise multivariate analysis of all 31 parameters assessed from three different gait paradigms, showed weak but significant correlations in age with (i) stride-to-stride variability in (i) integrated-pressure of footsteps and (ii) stride-length during steady-state gait, (iii) mean stride-length on dual-task, and (iv) mean step-width on tandem gait (R2= 0.382, t = 2.26, p = 0.026).SignificanceIn a population of healthy subjects without prior history of falls or medical illness that should affect gait, there were weak but significant age-related changes in objective measures of steady state gait and balance. Future prospective longitudinal data will help predict the relevance of this in relation to falls in the elderly.