Decline in lung function in the Busselton Health Study - The effects of asthma and cigarette smoking
Decline in lung function in the Busselton Health Study - The effects of asthma and cigarette smoking
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DOI：
10.1164/rccm.200402-230oc
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发表时间：
2005-01-15
影响因子：
24.7
通讯作者：
Musk, AW
中科院分区：
文献类型：
--
作者：
James, AL;Palmer, LJ;Musk, AW
成人哮喘可能与慢性气流阻塞有关，这可能是由于早期气道疾病和/或与哮喘患者相比，成人肺功能下降率更高。治疗和吸烟也可能影响肺功能下降速度。该分析的目的是检查成人哮喘和吸烟的肺功能水平和下降率。受试者（n = 9,317）作为成年人（> 18岁）参加了1966年至1981年之间的一个或多个横断面Busselton健康调查或1994/1995的后续研究。在线性混合效应模型中检查了性别，诊断性哮喘，吸烟状况和人体测量数据对FEV1的水平和下降率的影响。在19岁那年，哮喘受试者的FEV1减少了，但吸烟者和非吸烟者相似。随着年龄的增长，FEV1的男性，较高的受试者，吸烟者和哮喘受试者的下降幅度更大。吸烟和哮喘对下降具有添加性但没有倍增的影响。因此，哮喘与成人生活开始时的肺功能降低以及成人生活中的下降率有关。
Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of this analysis was to examine the level and rate of decline in lung function in relationship to asthma and cigarette smoking in adults. Subjects (n = 9,317) had participated as adults (> 18 years) in one or more of the cross-sectional Busselton Health Surveys between 1966 and 1981 or in the follow-up study of 1994/1995. The effects of sex, doctor-diagnosed asthma, smoking status, and anthropometric data on the level and rate of decline in FEV1 were examined in a linear mixed effects model. At the age of 19 years, FEV1 was reduced in subjects with asthma but was similar in smokers and nonsmokers. Males, taller subjects, smokers, and subjects with asthma had greater declines in FEV1 with age. Smoking and asthma had additive but not multiplicative effects on decline. Thus, asthma is associated with reduced lung function at the beginning of adult life as well as an increased rate of decline during adult life.