Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle
Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle
复制标题
DOI：
10.1097/hjh.0b013e3280e126bf
复制
发表时间：
2007-06-01
影响因子：
4.9
通讯作者：
Kohzuki, Masahiro
中科院分区：
文献类型：
--
作者：
Minami, Naoyoshi;Li, Yingyu;Kohzuki, Masahiro
目的体质与心血管健康密切相关。本研究探讨了血管紧张素转换酶抑制剂、运动训练及其联合应用对自发性高血压大鼠（SHR）运动能力、骨骼肌纤维类型和毛细血管形成的影响。久坐对照组（C）、培哚普利治疗组（3 mg/kg/天）（Per）、跑步机运动训练组（EX）及其联合治疗组（Per + EX）。干预8周后，大鼠在跑步机上进行逐步运动试验。实验结束后，对比目鱼肌的纤维类型和毛细血管功能进行了检测。与培哚普利单用相比，运动训练和培哚普利联合使用进一步提高了运动能力，而EX和Per + EX之间的运动能力无显著差异。与C相比，Per和EX的毛细血管密度增加相似。与单独运动训练相比，运动训练和培哚普利的组合进一步增加毛细血管密度。I型纤维的百分比增加，只有在每+ EX。结论我们发现，在不断增长的SHR，培哚普利慢性治疗增强未经训练的运动能力，而它不影响后天的运动能力，由于运动训练。我们还发现培哚普利促进骨骼肌对运动的适应性变化，如毛细血管密度和I型纤维百分比的增加。
Objective Physical fitness is closely related with cardiovascular health. We examined the effects of angiotensin-converting enzyme inhibitor, exercise training and their combination on exercise capacity as well as skeletal muscle fiber type and capillarity in spontaneously hypertensive rats (SHR).Methods Seven-week-old male SHR were allocated to four groups: sedentary control (C), treatment with perindopril (3 mg/kg per day) (Per), exercise training on a treadmill (EX), and their combination (Per + EX). Following 8-week interventions, rats were submitted to a stepwise exercise test on a treadmill. After experiments, fiber type and capillarity in soleus muscle were examined.Results Exercise capacity significantly increased in Per compared with in C. Combination of exercise training and perindopril further increased exercise capacity compared with perindopril alone, whereas there was no significant difference in exercise capacity between EX and Per + EX. Capillary density increased similarly in Per and EX compared with in C. Combination of exercise training and perindopril further increased capillary density compared with exercise training alone. The percentage of type I fiber increased only in Per+ EX.Conclusions We found that in growing SHR, chronic treatment with perindopril enhances untrained exercise capacity, while it does not affect acquired exercise capacity as a result of exercise training. We also found that perindopril promotes adaptive changes of skeletal muscle in response to exercise such as increases in capillary density and percentage of type I fiber.