The molecular orchestra of the migration of oligodendrocyte precursors during development
The molecular orchestra of the migration of oligodendrocyte precursors during development
复制标题
DOI：
10.1016/j.brainresrev.2004.12.034
复制
发表时间：
2005-09-01
影响因子：
--
通讯作者：
Bribián, A
中科院分区：
文献类型：
--
作者：
de Castro, F;Bribián, A
在中枢神经系统（CNS）的发育过程中，有丝分裂后细胞（包括神经元和髓磷脂生成细胞，少突胶质细胞）从它们起源的神经管生发区域迁移到最终目的地。神经元在发育过程中的迁移已被广泛研究，并已成为详细综述的主题。少突胶质前体细胞（oligodendrocytes precursor cells, OPCs）的迁移也是一个极其复杂和精确的事件，OPCs在许多区域广泛迁移，并定植整个中枢神经系统。不同的机制已经被证明可以指导OPCs的迁移，其中包括接触介导的机制（粘附分子）和远程提示（趋化分子）。本文对OPCs在发育过程中迁移的细胞和分子基础进行了详细的综述和讨论。由于已经证明神经元和少突胶质细胞谱系共享这些机制的一些，我们简要地总结了这两种类型的神经细胞之间的异同。我们还总结了OPCs在发育过程中正常迁移的变化，这可能与不同的神经系统疾病（包括脱髓鞘疾病，如多发性硬化症和神经胶质癌）有关。我们还研究了少突胶质细胞谱系的这些迁移特性与神经损伤修复的相关性。(c) 2005 Elsevier B.V.版权所有
During development of the central nervous system (CNS), postmitotic cells (including neurons and myelin-generating cells, the oligodendrocytes) migrate from the germinal areas of the neural tube where they originate to their final destination sites. The migration of neurons during development has been extensively studied and has been the topic of detailed reviews. The migration of oligodendrocyte precursor cells (OPCs) is also an extremely complex and precise event, with a widespread migration of OPCs across many regions to colonize the entire CNS. Different mechanisms have been shown to direct the migration of OPCs, among them contact-mediated mechanisms (adhesion molecules) and long-range cues (chemotropic molecules). This review provides a detailed overview and discussion of the cellular and molecular basis of OPCs migration during development. Because it has been shown that neuronal and oligodendroglial lineages share some of these mechanisms, we briefly summarize similarities and differences between these two types of neural cells. We also summarize the changes in the normal migration of OPCs during development that would be relevant for different neurological diseases (including demyelinating diseases, such as multiple sclerosis, and glial cancers). We also examine the relevance of these migratory properties of the oligondendrocytic cell lineage for the repair of neural damage. (c) 2005 Elsevier B.V. All rights reserved.