Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.
Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.
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DOI：
10.1186/1472-6831-5-5
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发表时间：
2005-07-07
期刊：
影响因子：
2.9
通讯作者：
Anand P
中科院分区：
文献类型：
--
作者：
Renton T;Yiangou Y;Plumpton C;Tate S;Bountra C;Anand P
河豚毒素抗性电压门控钠通道Nav1.8（SNS 1/PN 3）由伤害感受器表达，并可能在疼痛状态中发挥作用。使用免疫组化的特异性抗体，我们研究了Nav1.8 -免疫反应在人类牙髓神经元标记神经丝。从总共22名患者（14名无牙痛患者，8名牙痛患者）的牙齿中提取人牙髓。疼痛组图像分析中Nav1.8免疫反应性纤维显著增加：Nav1.8与神经丝%面积比中位数（范围），非疼痛组0.059（0.006-0.24），疼痛组0.265（0.13-0.5），P = 0.0019。Nav1.8钠通道可能因此代表三叉神经疼痛状态的治疗靶点。
The tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. Using specific antibodies for immunohistochemistry, we studied Nav1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain). Fibres immunoreactive for Nav1.8, were significantly increased on image analysis in the painful group: median (range) Nav1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019. Nav1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states.