Prostaglandin‐mediated inhibition of noradrenaline release
Prostaglandin‐mediated inhibition of noradrenaline release
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前列腺素介导的去甲肾上腺素释放抑制
DOI：
10.1111/j.1748-1716.1979.tb06339.x
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Å. Wennmalm
中科院分区：
文献类型：
--
作者：
Å. Wennmalm
研究了前列腺素（PG）合成抑制剂吲哚美辛对健康人某些心血管反射的影响。心率（HR）和呼吸性窦性心律不齐（RSA）在基础状态和颈动脉刺激（颈部抽吸），Valsalva比率，并在心率和血压（BP）的变化，在直立试验前和一个小时后的吲哚美辛（1.5毫克/公斤）。通过分析花生四烯酸诱导的血小板聚集来监测PG合成抑制剂的功效。吲哚美辛后基础心率无变化，刺激颈动脉可降低心率，且吲哚美辛前后的作用幅度相同。RSA的振幅不受吲哚美辛的影响，无论是在基础状态或在颈动脉刺激。用药前后，立位试验期间的瓦尔萨尔瓦比以及心率和血压的变化相似。去甲肾上腺素的循环水平不受吲哚美辛的影响。这些数据表明，PG生物形成的抑制在人不影响主要的心血管反射。因此，他们不赞成内源性形成的PG参与心血管调节的传入、中枢或传出通路的正常活动的假设。
The effect of indomethacin, a prostaglandin (PG) synthesis inhibitor, on some cardiovascular reflexes was studied in healthy subjects. Heart rate (HR) and respiratory sinus arrhythmia (RSA) in the basal state and during carotid stimulation (neck suction), Valsalva ratio, and changes in heart rate and blood pressure (BP) during an orthostatic test were measured before and one hour after administration of indomethacin (1.5 mg/kg). The efficacy of the PG synthesis inhibitor was monitored by analysis of platelet aggregation induced by arachidonic acid. Following indomethacin no change was observed in basal HR. Carotid stimulation depressed the HR and this effect was of the same amplitude before and after indomethacin. The amplitude of RSA was not affected by indomethacin, either in the basal state or during carotid stimulation. The Valsalva ratio and the changes in HR and BP during the orthostatic test were similar before and after the drug. Circulating levels of noradrenaline were unaffected by indomethacin. These data demonstrate that inhibition of PG bioformation in man does not affect major cardiovascular reflexes. Consequently they disfavour the hypothesis that endogenously formed PG would be involved in the normal activity of the afferent, central or efferent pathways for cardiovascular regulation.