A mild and effective iodination method using iodine in the presence of bis-(trifluoroacetoxy)iodobenzene
A mild and effective iodination method using iodine in the presence of bis-(trifluoroacetoxy)iodobenzene
复制标题
DOI：
10.1016/s0040-4039(98)01494-4
复制
发表时间：
1998-09-17
影响因子：
1.8
通讯作者：
Fourrey, JL
中科院分区：
文献类型：
--
作者：
Benhida, R;Blanchard, P;Fourrey, JL
本文描述了一种温和而有效的碘化方法，该方法以双(三氟乙酰氧基)碘苯-碘为试剂，应用于缺电子杂环体系(受保护的吲哚、香豆素等)。此外，在新的碘化反应条件下，乙酰基和叔丁基二甲基硅基等敏感保护基团是稳定的。(C)1998爱思唯尔科学有限公司。保留所有权利。
Herein is described a mild and effective iodination method using bis-(trifluoroacetoxy)iodobenzene-iodine as reagent to be applied to electron deficient heterocyclic systems (protected indoles, coumarin...). Moreover, sensitive protecting groups such as acetyl and tert-butyldimethylsilyl were found to be stable under the new iodination reaction conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.