Following the organism to map synthetic genomics
Following the organism to map synthetic genomics
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DOI：
10.1016/j.biotno.2022.07.001
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
Maya Hey;E. Szymanski
中科院分区：
文献类型：
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作者：
Maya Hey;E. Szymanski
合成基因组学，或在整个基因组和整个生物体水平上的工程生物学，是基于部分的合成生物学的新兴产物。这个新兴的子领域也是多样化的，很难描述。作为研究合成基因组学中负责任的研究和创新的社会科学家，我们认为关注生物体是理解其所包含的多样性的富有成效的方法。在这里，我们提供了一个启发式的标记系统的形式来组织工程生物体被要求执行的角色的项目。我们提出了几个原因，为什么这个系统是有用的了解该领域的当前形状和未来的发展方向，特别是在需要问：工程生物学如何有助于建立一个可持续发展的关系与其他生物的未来？
Synthetic genomics, or engineering biology at the level of whole genomes and whole organisms, is an emerging outgrowth of parts-based synthetic biology. This nascent subfield is also diverse and difficult to characterize. As social scientists investigating responsible research and innovation in synthetic genomics, we suggest that focusing on the organism is a fruitful approach to making sense of the diversity it encompasses. Here, we offer a heuristic in the form of a tagging system to organize projects by the roles the engineered organism is asked to perform. We suggest several reasons why this system is useful for understanding the current shape and future directions of the field, especially in light of the need to ask: how does engineering biology contribute to building a future of sustainable relationships with other creatures?