Use of 18FDG-PET to discriminate between infection and rejection in lung transplant recipients
Use of 18FDG-PET to discriminate between infection and rejection in lung transplant recipients
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DOI：
10.1097/01.tp.0000121767.05724.33
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发表时间：
2004-05-15
期刊：
影响因子：
6.2
通讯作者：
Chilvers, ER
中科院分区：
文献类型：
--
作者：
Jones, HA;Donovan, T;Chilvers, ER
通过正电子发射断层扫描（PET）测量的F-18-氟脱氧葡萄糖（（18）FDG）摄取可以评估体内中性粒细胞活性，并在气道炎症或感染患者中增加。由于感染而非排斥反应可引起高度嗜肺细胞反应，我们评估了这种非侵入性技术在肺移植受者中区分这两种事件的能力。（18）对15例根据临床、影像学和病理标准分类的患者进行FDG-PET测量。（18）FDG-PET信号在确诊感染时增加，而在未确诊感染时则无此变化（平均值[平均值的标准误差]分别为：8.00 [1.81]和3.16 [0.61][P=0.021]）。单是拒绝并不能增加信号。这些数据证实中性粒细胞活化不是急性排斥反应的特征，并表明高（18）FDG-PET信号指示肺移植受者中的感染而不是排斥反应。这种非侵入性和可重复的测试可以减少肺移植后呼吸困难发作期间所需的经支气管活检的数量。
F-18-fluorodeoxyglucose ((18)FDG) uptake measured by positron emission tomography (PET) allows assessment of neutrophil activity in vivo and is increased in patients with airway inflammation or infection. Because infection but not rejection elicits a highly neutrophilic response, we assessed the ability of this noninvasive technique to differentiate these two events in lung transplant recipients. (18)FDG-PET was measured in 15 patients classified by clinical, radiologic, and pathologic criteria. (18)FDG-PET signal was increased with proven infection but not when no infection was identified (mean [standard error of mean]: 8.00 [1.81] and 3.16 [0.61], respectively [P=0.021]. Rejection alone did not increase the signal. These data confirm that neutrophil activation is not a feature of acute rejection and indicate that a high (18)FDG-PET signal is indicative of infection but not rejection in lung transplant recipients. This non-invasive and repeatable test could reduce the number of transbronchial biopsies required during episodes of breathlessness after lung transplantation.