Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats.
Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats.
复制标题
西尼地平与尼卡地平、硝苯地平在加压素诱发的大鼠心绞痛模型中抗心绞痛作用的比较。
DOI：
10.1007/s00380-016-0848-4
复制
发表时间：
2016
影响因子：
1.5
通讯作者：
Sugiyama A.
中科院分区：
文献类型：
--
作者：
Cao X;Nakamura Y;Wada T;Izumi-Nakaseko H;Ando K;Zhu B;Xu B;Takahara A;Saitoh M;Sugiyama A.
We assessed the anti-anginal effects of cilnidipine in comparison with those of nicardipine and nifedipine (1 and 10 µg/kg,n= 6 for each drug) or vehicle (n= 6) by using the vasopressin-induced angina model of rats. The administration of vasopressin (0.5 IU/kg, i.v.) to the rats depressed the S-wave level of the electrocardiogram reflecting the presence of subendocardial ischemia, whereas it significantly increased the mean blood pressure, resulting in the decrease of the heart rate and the prolongation of the PR interval possibly through a reflex–mediated increase in vagal tone. Cilnidipine suppressed the vasopressin-induced depression of the S-wave level in a dose-related manner, which was not observed by nicardipine or nifedipine. In addition, the low dose of cilnidipine hardly affected the vasopressin-induced pressor response, but it attenuated the negative dromotropic effect, suggesting N-type Ca2+channel inhibition by cilnidipine might have suppressed the parasympathetic nerve activity in vivo like those reported in the sympathetic nerve. Thus, cilnidipine may become a useful strategy for inhibiting coronary vasospasm-induced anginal attack.
