NALOXONE STIMULATES OXYGEN-CONSUMPTION BUT NOT VENTILATION IN HYPOTHYROID HAMSTERS
NALOXONE STIMULATES OXYGEN-CONSUMPTION BUT NOT VENTILATION IN HYPOTHYROID HAMSTERS
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DOI：
10.1016/0031-9384(94)90218-6
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发表时间：
1994-10-01
影响因子：
2.9
通讯作者：
BURBACH, JA
中科院分区：
文献类型：
--
作者：
SCHLENKER, EH;MEANS, R;BURBACH, JA
用丙基硫氧嘧啶（PTU）治疗雄性叙利亚金黄地鼠5周，造成甲状腺功能减退，对照组给予自来水。两组9只动物均显示，与生理盐水处理相比，纳洛酮SC给药后的耗氧量增加，纳洛酮刺激通气和通气对对照仓鼠的低氧（10% O-2）和高氧、高碳酸（7% CO2，含氧）挑战有反应。相对于它们对生理盐水的反应，PTU处理的仓鼠在纳洛酮处理后没有表现出通气刺激，也没有表现出对气体激发的通气刺激。这些结果表明：（a）纳洛酮对氧消耗的刺激不会直接增加通气;（B）仓鼠的甲状腺激素状态影响阿片类药物对通气的调节。
Male golden Syrian hamsters made hypothyroid by 5 wk of propylthiouracil (PTU) treatment and control hamsters given tap water were studied. Both groups of nine animals demonstrated increased oxygen consumption after SC naloxone administration relative to saline treatment Naloxone stimulated ventilation and ventilation in response to hypoxic (10% O-2) and hyperoxic, hypercapnic (7% CO2 in oxygen) challenges in control hamsters. Relative to their responses to saline, PTU-treated hamsters exhibited no stimulation of ventilation nor of ventilation in response to the gas challenges after naloxone treatment. These results suggest that (a) the stimulation of oxygen consumption by naloxone does not directly increase ventilation; and (b) thyroid hormone status in the hamster affects opioid modulation of ventilation.