Chemokine decoy receptors: New players in reproductive immunology
Chemokine decoy receptors: New players in reproductive immunology
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DOI：
10.1080/08820130802191318
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Locati, Massimo
中科院分区：
文献类型：
--
作者：
Borroni, Elena Monica;Bonecchi, Raffaella;Locati, Massimo
趋化因子是多功能分子，在白细胞运输和发育过程中发挥作用。胎盘的胎儿和母体成分都产生趋化因子，其控制胎盘中观察到的白细胞运输。因此，趋化因子在保护发育中的胚胎/胎儿与其半同种异体组织的耐受性之间的平衡中发挥作用。最近，一组趋化因子受体，其中包括D 6，DARC，和CCX-CKR，已被描述为沉默受体，由于它们不能激活信号转导事件，导致细胞化学吸引。在这里，我们回顾在体外和体内的证据表明，趋化因子沉默受体调节先天性和适应性免疫表现为诱饵受体，支持内化和降解的趋化因子，并讨论其在生殖免疫学的潜在作用的现有信息。
Chemokines are multifunctional molecules with roles in leukocyte trafficking and developmental processes. Both fetal and maternal components of the placenta produce chemokines, which control leukocyte trafficking observed in the placenta. Thus, chemokines play roles in the balance between protection of the developing embryo/fetus and tolerance of its hemiallogeneic tissues. Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as silent receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction. Here we review in vitro and in vivo evidence indicating that chemokine silent receptors regulate innate and adaptive immunity behaving as decoy receptors that support internalization and degradation of chemotactic factors, and discuss available information on their potential role in reproductive immunology.