Presence of human papillomavirus type‐16 and type‐18 DNA sequences and their expression in cervical cancers and cell lines from japanese patients
Presence of human papillomavirus type‐16 and type‐18 DNA sequences and their expression in cervical cancers and cell lines from japanese patients
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人乳头瘤病毒 16 型和 18 型 DNA 序列的存在及其在日本患者宫颈癌和细胞系中的表达
DOI：
10.1002/ijc.2910370405
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发表时间：
1986
影响因子：
6.4
通讯作者：
T. Sugimura
中科院分区：
文献类型：
--
作者：
Y. Tsunokawa;N. Takebe;S. Nozawa;T. Kasamatsu;L. Gissmann;H. Hausen;M. Terada;T. Sugimura
对日本患者宫颈癌手术标本的Southern印迹分析显示，3/9份样本含有人乳头瘤病毒（HPV）16型DNA序列，2份含有HPV 18型DNA序列。通过北方印迹分析，在一些含有HPV 16型或HPV 18型DNA序列的组织中发现了HPV DNA序列的RNA转录物。从日本患者宫颈癌中建立的两种细胞系也含有HPV 18型基因组，这些细胞系含有HPV 18型转录物。来自日本患者的另外两种宫颈癌细胞系被发现含有HPV 16型DNA序列及其RNA转录物。
Southern blot analyses of surgical specimens of cervical carcinoma from Japanese patients showed that 3/9 samples contained human papillomavirus (HPV) type‐16 DNA sequences, and 2 contained HPV type‐18 DNA sequences. By Northern blot analyses, RNA transcripts of HPV DNA sequences were demon‐trated in some of the tissues containing HPV type‐16 or HPV type‐18 DNA sequences. Two cell lines established from cervical cancers of Japanese patients also contained HPV type‐18 genomes and these cell lines contained HPV type‐18 transcripts. Two other cervical cancer cell lines from a Japanese patient were found to contain HPV type‐16 DNA sequences and their RNA transcripts.
宫颈癌的组织学类型和人乳头瘤病毒 DNA 的检测。
影响因子：
11.2
作者：
Fukushima,M;Okagaki,T;Twiggs,LB;Clark,BA;Zachow,KR;Ostrow,RS;Faras,AJ
通讯作者：
Faras,AJ
新建立的宫颈癌细胞系 (SKG-III)，具有 Regan 同工酶、人绒毛膜促性腺激素 β 亚基和妊娠特异性 β 1 糖蛋白表型。
影响因子：
11.2
作者：
Nozawa,S;Udagawa,Y;Ohta,H;Kurihara,S;Fishman,WH
通讯作者：
Fishman,WH