Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques
Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques
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DOI：
10.1111/j.1399-0039.2008.01168.x
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发表时间：
2009-02-01
期刊：
影响因子：
--
通讯作者：
Chen, L.
中科院分区：
文献类型：
--
作者：
Ma, X.;Tang, L. H.;Chen, L.
恒河猴(Macaca Mulatta)是人类疾病和疫苗研究的重要动物模型。虽然中国猕猴和印度猕猴是同一物种，但它们来自不同的地理种群，具有不同的主要组织相容性复合体(MHC)I类A等位基因。在对65只中国恒河猴的分析中，发现了17个新的Mamu-A等位基因，它们的登录号如下：EU252155-158、EU262737-741、EU418504-505、EU422996、EU418506、EU753185-187和EU828528。这些额外的MHC I类A序列的发现表明中国恒河猴在不同地理位置具有更大的多样性和多态。由于中国猕猴的Mamu-A等位基因不同于印度动物的Mamu-A等位基因，在疫苗研究方面，这些新的等位基因限制性免疫反应仍需进行更多的工作。
Rhesus macaques (Macaca mulatta) serve as important animal models for human disease and vaccine research. Although Chinese rhesus macaques are the same species as those of Indian origin, they are from a geographically separated population and possess divergent major histocompatibility complex (MHC) class I A alleles. In an analysis of 65 Chinese rhesus macaques, 17 novel Mamu-A alleles were identified and deposited under the following accession numbers: EU252155-158, EU262737-741, EU418504-505, EU422996, EU418506, EU753185-187, and EU828528. The discovery of these additional MHC class I A sequences indicates a greater diversity and polymorphism of Chinese rhesus macaques in different geographic locations. As the set of Mamu-A alleles in Chinese rhesus macaques differs from the alleles of Indian animals, more work still needs to be carried out to identify these new allele-restricted immune responses with regard to vaccine studies.