Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers.
Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers.
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DOI：
10.1289/ehp.9032
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发表时间：
2006-08
影响因子：
10.4
通讯作者：
Koizumi, Akio
中科院分区：
文献类型：
--
作者：
Inoue, Kayoko;Harada, Kouji;Takenaka, Katsunobu;Uehara, Shigeki;Kono, Makoto;Shimizu, Takashi;Takasuga, Takumi;Senthilkumar, Kurunthachalam;Yamashita, Fumiyoshi;Koizumi, Akio
血液和/或母乳已被用于评估人类暴露于各种环境污染物。很少有研究比较一种基质与另一种基质中的浓度。本研究的目的是确定日本妇女目前的多溴联苯醚（PBDEs）和多氯联苯（PCBs）水平，分析生活方式和饮食习惯对这些水平的影响，并建立定量结构活性关系（QSAR），预测血清浓度与母乳浓度的比值。我们测量了2005年在日本四个地区收集的89对血清和母乳样本中的多溴联苯醚和多氯联苯。牛奶和血清中多溴二苯醚（13种同系物）总浓度的几何平均值分别为1.56和2.89纳克/克脂重，而多氯联苯（15种同系物）总浓度的几何平均值分别为63.9和37.5纳克/克脂重。血清和牛奶中多溴联苯醚总浓度的主要决定因素是日本国内的地理区域，而哺乳时间是多氯联苯浓度的主要决定因素。BDE-209是血清中最主要的多溴二苯醚同系物，但不是牛奶中的同系物。牛奶中BDE 209的排泄量低于BDE 47和BDE 153。定量构效关系分析表明，两个参数，计算的辛醇/水分配和氢键受体的数量，是显着的描述符。在哺乳期的第一周，多溴二苯醚和多氯联苯同系物从血清到乳汁的预测分配与观察值一致。然而，在10周的护理后，预测变得更弱。
Blood and/or breast milk have been used to assess human exposure to various environmental contaminants. Few studies have been available to compare the concentrations in one matrix with those in another. The goals of this study were to determine the current levels of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in Japanese women, with analysis of the effects of lifestyle and dietary habits on these levels, and to develop a quantitative structure–activity relationship (QSAR) with which to predict the ratio of serum concentration to breast milk concentration. We measured PBDEs and PCBs in 89 paired samples of serum and breast milk collected in four regions of Japan in 2005. The geometric means of the total concentrations of PBDE (13 congeners) in milk and serum were 1.56 and 2.89 ng/g lipid, respectively, whereas those of total PCBs (15 congeners) were 63.9 and 37.5 ng/g lipid, respectively. The major determinant of total PBDE concentration in serum and milk was the geographic area within Japan, whereas nursing duration was the major determinant of PCB concentration. BDE-209 was the most predominant PBDE congener in serum but not in milk. The excretion of BDE 209 in milk was lower than that of BDE 47 and BDE 153. QSAR analysis revealed that two parameters, calculated octanol/water partition and number of hydrogen-bond acceptors, were significant descriptors. During the first weeks of lactation, the predicted partitioning of PBDE and PCB congeners from serum to milk agreed with the observed values. However, the prediction became weaker after 10 weeks of nursing.