Production of experimental endocarditis by coagulase-negative staphylococci: variability in species virulence.
Production of experimental endocarditis by coagulase-negative staphylococci: variability in species virulence.
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凝固酶阴性葡萄球菌引起实验性心内膜炎：物种毒力的变异。
DOI：
10.1093/infdis/150.5.721
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bisno,AL
中科院分区：
文献类型：
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作者：
Baddour,LM;Christensen,GD;Hester,MG;Bisno,AL
比较了11株凝固酶阴性葡萄球菌分离株在大鼠模型中建立感染性心内膜炎的能力。其中7个菌株是表皮葡萄球菌，这是最常见的导致人类心内膜炎的菌株。其他四种菌株是人葡萄球菌，一种罕见的心内膜炎的原因。7株S.四株人链球菌中有两株为表面粘液。接种107个菌落形成单位的S.在40只注射了人链球菌的动物中，仅有5只（12.5%）出现了表皮炎（P<0.001）。S.在体外实验中，表皮葡萄球菌对吞噬细胞杀伤的抵抗力显著高于S.人类这些数据表明，在体内和体外，不同种属的凝固酶阴性葡萄球菌的毒力存在重大差异，这些差异反映在观察到的各种属在人体中引起的疾病发生率中。
The abilities of 11 coagulase-negative staphylococcal isolates of human origin to establish infective endocarditis in a rat model were compared. Seven of the strains wereStaphylococcus epidermidis, the species most commonly causing endocarditis in humans. The other four strains wereStaphylococcus hominis, an infrequent cause of endocarditis. Four of the seven strains ofS. epidermidisand two of the four strains of S.hominiselaborated surface slime. With an inoculum of 107colony-forming units, endocarditis was established in all of 77 rats injected withS. epidermidisbut in only five (12.5%) of 40 animals injected with S.hominis(P< .001). Strains ofS. epidermidiswere significantly more resistant to phagocytic killing in vitro than were strains ofS. hominis. These data indicate that there are major differences in the virulence of various species of coagulase-negative staphylococci, both in vivo and in vitro, and that these differences are reflected in the observed incidence of disease caused in humans by the respective species.