Altered tract-specific white matter microstructure is related to poorer cognitive performance: The Rotterdam Study
Altered tract-specific white matter microstructure is related to poorer cognitive performance: The Rotterdam Study
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DOI：
10.1016/j.neurobiolaging.2015.11.021
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发表时间：
2016-03-01
影响因子：
4.2
通讯作者：
Ikram, M. Arfan
中科院分区：
文献类型：
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作者：
Cremers, Lotte G. M.;de Groot, Marius;Ikram, M. Arfan
白色物质的微结构完整性与认知有关。然而，在全球白色物质效应之上的特定白色物质束的潜在作用仍然不清楚，特别是在考虑特定的认知领域时。因此，我们确定了白色物质微结构对整体认知和特定认知领域的特定影响。在4400名非痴呆和无卒中的参与者（平均年龄63.7岁，55.5%为女性）中，我们使用概率纤维束成像获得了14条白色物质束的弥散磁共振成像参数（各向异性分数和平均弥散度），并使用认知测试组合评估了认知能力。所有幕上神经束的特定白色物质微结构与较差的整体认知相关。较低的分数各向异性的联合道，主要是下额枕束，和较高的平均扩散率的投影道，特别是后丘脑辐射，最强烈相关的较差的认知。改变的白色物质微观结构与较差的信息处理速度、执行功能和运动速度有关，但与记忆无关。特定区域的微结构变化可能有助于更好地理解认知障碍和神经退行性疾病的机制。(C)2016 Elsevier Inc. All rights reserved.
White matter microstructural integrity has been related to cognition. Yet, the potential role of specific white matter tracts on top of a global white matter effect remains unclear, especially when considering specific cognitive domains. Therefore, we determined the tract-specific effect of white matter microstructure on global cognition and specific cognitive domains. In 4400 nondemented and stroke-free participants (mean age 63.7 years, 55.5% women), we obtained diffusion magnetic resonance imaging parameters (fractional anisotropy and mean diffusivity) in 14 white matter tracts using probabilistic tractography and assessed cognitive performance with a cognitive test battery. Tract-specific white matter microstructure in all supratentorial tracts was associated with poorer global cognition. Lower fractional anisotropy in association tracts, primarily the inferior fronto-occipital fasciculus, and higher mean diffusivity in projection tracts, in particular the posterior thalamic radiation, most strongly related to poorer cognition. Altered white matter microstructure related to poorer information processing speed, executive functioning, and motor speed, but not to memory. Tract-specific microstructural changes may aid in better understanding the mechanism of cognitive impairment and neurodegenerative diseases. (C) 2016 Elsevier Inc. All rights reserved.