Does anodal transcranial direct current stimulation modulate sensory perception and pain? A meta-analysis study
Does anodal transcranial direct current stimulation modulate sensory perception and pain? A meta-analysis study
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DOI：
10.1016/j.clinph.2014.01.020
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发表时间：
2014-09-01
影响因子：
4.7
通讯作者：
Jaberzadeh, S.
中科院分区：
文献类型：
--
作者：
Vaseghi, B.;Zoghi, M.;Jaberzadeh, S.
目的：本系统综述的主要目的是评估阳极经颅直流电刺激（a-tDCS）对健康个体感觉（STh）和疼痛阈值（PTh）以及慢性疼痛患者疼痛水平（PL）的影响。方法：检索电子数据库中有关a-tDCS的研究。使用PEDro and Downs and Black （D&B）评估工具检查方法学质量。结果：初级运动皮层（M1）的a-tDCS增加了STh （P < 0.005，效应量为22.19%）和PTh （P < 0.001，效应量为19.28%）。此外，a-tDCS对初级感觉皮层（S1）有显著的刺激作用（P < 0.05，效应量为4.34）。同样，在将a-tDCS应用于M1和背外侧前额叶皮层（DLPFC）后，患者组的PL显著降低。在M1和DLPFC应用a-tDCS后，视觉模拟评分平均下降14.9%和19.3%。此外，meta分析显示，在所有亚组中（除了S1的a-tDCS），活跃的a-tDCS和假刺激产生显著差异。结论：本综述为a-tDCS提高健康组STh/PTh和降低患者PL的有效性提供了证据。然而，由于纳入研究的样本量较小，我们的结果应谨慎解释。考虑到纳入标准中未考虑盲化水平，本研究的结果应谨慎解释。意义：刺激部位对疼痛的缓解有不同的效果。(C) 2014年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有
Objective: The primary aim of this systematic review was to evaluate the effects of anodal transcranial direct current stimulation (a-tDCS) on sensory (STh) and pain thresholds (PTh) in healthy individuals and pain levels (PL) in patients with chronic pain.Methods: Electronic databases were searched for a-tDCS studies. Methodological quality was examined using the PEDro and Downs and Black (D&B) assessment tools.Results: a-tDCS of the primary motor cortex (M1) increases both STh (P < 0.005, with the effect size of 22.19%) and PTh (P < 0.001, effect size of 19.28%). In addition, STh was increased by a-tDCS of the primary sensory cortex (S1) (P < 0.05 with an effect size of 4.34). Likewise, PL decreased significantly in the patient group following application of a-tDCS to both the M1 and dorsolateral prefrontal cortex (DLPFC). The average decrease in visual analogue score was 14.9% and 19.3% after applying a-tDCS on the M1 and DLPFC. Moreover, meta-analysis showed that in all subgroups (except a-tDCS of S1) active a-tDCS and sham stimulation produced significant differences.Conclusions: This review provides evidence for the effectiveness of a-tDCS in increasing STh/PTh in healthy group and decreasing PL in patients. However, due to small sample sizes in the included studies, our results should be interpreted cautiously. Given the level of blinding did not considered in inclusion criteria, the result of current study should be interpreted with caution.Significance: Site of stimulation should have a differential effect over pain relief. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved