Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori
Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori
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DOI：
10.1128/aac.47.9.2984-2986.2003
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发表时间：
2003-09-01
影响因子：
4.9
通讯作者：
Kusters, JG
中科院分区：
文献类型：
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作者：
Gerrits, MM;Berning, M;Kusters, JG
幽门螺杆菌16 S rDNA三碱基突变阿加（926-928）-->TTC介导高水平四环素耐药相比之下，单碱基对和双碱基对突变仅介导低水平的四环素抗性，并在四环素存在下降低生长速率，解释了四环素抗性H.幽门螺杆菌分离株。
The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.