Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital.
Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital.
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德岛大学附属医院肺癌门诊化疗情况调查
DOI：
10.2152/jmi.58.219
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Y. Nishioka
中科院分区：
文献类型：
--
作者：
H. Goto;M. Hanibuchi;Satoshi Sakaguchi;T. Kanematsu;S. Kakiuchi;Hideki Tomimoto;M. Azuma;Toshifumi Tezuka;H. Tada;Y. Miki;Toshimi Nakamura;S. Sone;Y. Nishioka
在各种随机III期研究中，铂双联方案和多西他赛分别作为一线和二线化疗可延长肺癌患者的生存期。然而，在临床实践中，化疗对肺癌的疗效的证据仍然不足。在本研究中，我们调查了肺癌门诊化疗的有效性和安全性的临床实践。回顾性分析94例肺癌病例。其中非小细胞肺癌67例（71.3%），小细胞肺癌27例（28.7%）。小细胞肺癌和非小细胞肺癌的有效率分别为55.6%（15/27）和16.9%（11/65）。如前所述，发现患者的客观肿瘤缓解率随着每种治疗线的使用而显著降低。所有不良事件均耐受良好，未观察到治疗相关死亡。SCLC和NSCLC一线治疗的中位至治疗失败时间（TTF）分别为10.1个月和4.8个月。这些发现表明，即使在临床实践中，化疗的有效性和安全性是严格保证适当的治疗管理。
Platinum-doublet regimens and docetaxel as first- and second-line chemotherapy, respectively, are shown to prolong the survival of lung cancer patients in various randomized phase III studies. However, the evidence for the efficacy of chemotherapy for lung cancer in the clinical practice is still insufficient. In the present study, we investigated the effectiveness and safety of outpatient chemotherapy for lung cancer in the clinical practice. Ninety-four lung cancer cases were retrospectively analyzed. Among these cases, 67 (71.3%) were non-small cell lung cancer (NSCLC) and 27 (28.7%) were small cell lung cancer (SCLC). The response rates in SCLC and NSCLC patients were 55.6% (15/27) and 16.9% (11/65), respectively. Objective tumor response rates for the patients were found to decrease substantially with each line of treatment as described previously. All adverse events were well tolerated and no treatment-related death was observed. Median time to treatment failures (TTFs) of first-line treatment were 10.1 months and 4.8 months in SCLC and NSCLC, respectively. These findings indicate that even in the setting of clinical practice, the efficacy and safety of chemotherapy is strictly insured by the appropriate therapeutic management.
影响因子：
3.5
作者：
Trotti, A;Colevas, AD;Rubin, P
通讯作者：
Rubin, P
影响因子：
158.5
作者：
Schiller, JH;Harrington, D;Johnson, DH
通讯作者：
Johnson, DH