The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis.
The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis.
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DOI：
10.1016/j.fct.2016.02.012
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Yang C
中科院分区：
文献类型：
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作者：
Humphries B;Wang Z;Yang C
microRNA（miRNAs）是肿瘤发生的表观遗传学机制的重要组成部分，在肿瘤的发生、转移、预后和药物治疗反应中起着重要作用，可作为肿瘤早期诊断的生物标志物和肿瘤治疗的工具。金属致癌物，如砷、镉、六价铬和镍，是公认的人类致癌物，长期接触会导致各种癌症。然而，金属致癌的机制尚未得到很好的理解，这限制了我们有效诊断和治疗慢性金属致癌物暴露导致的人类癌症的能力。近年来，人们对miRNAs在金属致癌中的作用进行了积极探索，越来越多的证据表明miRNAs在金属致癌中起着重要作用。本文就近年来有关miRNAs在金属致癌物诱导的细胞恶性转化和肿瘤发生中的作用进行综述。最后对今后的研究提出了一些设想。
MicroRNAs (miRNAs), an important component of epigenetic mechanisms of carcinogenesis, have been shown to play crucial roles in cancer initiation, metastasis, prognosis and responses to drug treatment and may serve as biomarkers for early diagnosis of cancer and tools for cancer therapy. Metal carcinogens, such as arsenic, cadmium, hexavalent chromium and nickel, are well-established human carcinogens causing various cancers upon long term exposure. However, the mechanism of metal carcinogenesis has not been well understood, which limits our capability to effectively diagnose and treat human cancers resulting from chronic metal carcinogen exposure. Over recent years, the role of miRNAs in metal carcinogenesis has been actively explored and a growing body of evidence indicates the critical involvement of miRNAs in metal carcinogenesis. This review aims to discuss recent studies showing that miRNAs play important roles in metal carcinogen-induced cell malignant transformation and tumorigenesis. Some thoughts for future further studies in this field are also presented.