Sensory Inputs to Intercalated Cells Provide Fear-Learning Modulated Inhibition to the Basolateral Amygdala
Sensory Inputs to Intercalated Cells Provide Fear-Learning Modulated Inhibition to the Basolateral Amygdala
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DOI：
10.1016/j.neuron.2015.03.008
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发表时间：
2015-04-22
期刊：
影响因子：
16.2
通讯作者：
Ehrlich, Ingrid
中科院分区：
文献类型：
--
作者：
Asede, Douglas;Bosch, Daniel;Ehrlich, Ingrid
越来越多的证据表明，杏仁核中平行的可塑性过程涉及控制恐惧和消退记忆的抑制元素。GABA能内侧囊旁间质细胞(MpITCs)被认为在抑制恐惧的过程中传递来自基底外侧核(BLA)和前额叶皮质的活动，以抑制中央杏仁核的输出。最近，mpITCs在不同的恐惧状态下的投射多样性和不同的行为激活提示了额外的功能。在这里，我们发现，mpITCs接受丘脑和皮质的融合感觉输入，经历与恐惧学习相关的变化，并通过从mpITC网络释放的GABA招募的突触前GABA(B)受体进行动态调节。在mpITCs中，我们识别出抑制但也被BLA主神经元相互激活的细胞。因此，mpITCs参与恐惧学习调节的前馈和反馈抑制电路，以同时控制杏仁核的输入和输出核。我们的发现将mpITCs置于一个独特的位置，通过它们的直接感觉输入来控制后天获得的杏仁核依赖行为。
Increasing evidence suggests that parallel plastic processes in the amygdala involve inhibitory elements to control fear and extinction memory. GABAergic medial paracapsular intercalated cells (mpITCs) are thought to relay activity from basolateral nucleus (BLA) and prefrontal cortex to inhibit central amygdala output during suppression of fear. Recently, projection diversity and differential behavioral activation of mpITCs in distinct fear states suggest additional functions. Here, we show that mpITCs receive convergent sensory thalamic and cortical inputs that undergo fear learning-related changes and are dynamically modulated via presynaptic GABA(B) receptors recruited by GABA released from the mpITC network. Among mpITCs, we identify cells that inhibit but are also mutually activated by BLA principal neurons. Thus, mpITCs take part in fear learning-modulated feedforward and feedback inhibitory circuits to simultaneously control amygdala input and output nuclei. Our findings place mpITCs in a unique position to gate acquired amygdala-dependent behaviors via their direct sensory inputs.