d-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke A case-control study based on the STROBE guidelines
d-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke A case-control study based on the STROBE guidelines
复制标题
DOI：
10.1097/md.0000000000018779
复制
发表时间：
2020-01-01
期刊：
影响因子：
1.6
通讯作者：
Li, Tian
中科院分区：
文献类型：
--
作者：
Shen, Yijun;Li, Yuxia;Li, Tian
本研究的目的是评估中国和东亚地区癌症相关性缺血性卒中的危险因素并阐明其临床特征，以将其与传统缺血性卒中区分开来。在2012年6月至2016年6月期间，对609名患有癌症的中风患者进行了回顾性分析。将患者分为3组：癌症-脑卒中组（CSG，203例）、脑卒中组（SG，203例）和癌症组（CG，203例）。将d-二聚体水平和弥散加权成像病变（DWI）模式与年龄和性别匹配的对照组进行比较。最常见的癌症类型是结直肠癌（20.2%）和肺癌（18.72%）。脑卒中患者和癌症患者的平均D-二聚体水平分别为0.34和1.50 mg/L。D-二聚体水平从高到低依次为肺癌（2.06 mg/L）、胰腺癌（1.74 mg/L）、胃癌（1.61 mg/L）等。单因素分析显示，D-二聚体、DWI、高血压、糖尿病、血栓的患病率与CSG及其他因素有显著性差异。CSG具有独特的病理特征，包括高血浆D-二聚体水平和多血管病变。结果表明，d-二聚体和DWI可作为临床诊断指标。
The aim of this study was to evaluate the risk factors and elucidate the clinical characteristics of cancer-associated ischemic stroke to differentiate it from conventional ischemic stroke in China and East Asia. Between June 2012 and June 2016, a retrospective analysis was performed on 609 stroke patients with cancer. They were divided into 3 groups: cancer-stroke group (CSG, 203 cases), stroke group (SG, 203 cases), and cancer group (CG, 203 cases). The d-dimer levels and diffusion-weighted imaging lesion (DWI) pattern were compared to an age- and sex-matched control group. The most common cancer types were colorectal cancer (20.2%) and lung cancer (18.72%). The average d-dimer level in stroke patients and cancer patients were 0.34 and 1.50 mg/L, respectively. The descending levels of d-dimer from cancer types were lung cancer (2.06 mg/L), pancreas (1.74 mg/L), gastric (1.61 mg/L), among others. Univariate analysis of the CSG and the others shows there were significant differences in the prevalence of the levels of d-dimer and DWI pattern, hypertension, diabetes mellitus, and thrombus. CSG has a unique pathological characteristic including high plasma d-dimer levels and multiple vascular lesions. The results show that d-dimer and DWI can be used as diagnostic index in clinical practice.