Comparison of footbathing and vaccination to control ovine footrot in an experimentally infected flock
Comparison of footbathing and vaccination to control ovine footrot in an experimentally infected flock
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DOI：
10.1111/avj.12715
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发表时间：
2018-10-01
影响因子：
1.1
通讯作者：
Egerton, J. R.
中科院分区：
文献类型：
--
作者：
Allworth, M. B.;Egerton, J. R.
目的比较某羊群多株结状双杆菌故意感染传播期间足浴与预防接种对控制足疾的影响。方法菌株包括一株已知毒力菌株、一株良性菌株和数株中间菌株。由此产生的足步在临床上属于中等水平。1450只1-3岁的Polwarth羊被分为5个治疗组：未经治疗，每周进行硫酸锌足浴，每3周进行1小时的替代足浴，接种商业多价全细胞疫苗和接种新型重组DNA纤维疫苗。在四个围场中进行了四个重复实验。结果未经治疗的动物中，76%有足疾。每周一次或每3周进行一次足疗，将患病率分别限制在6/283（2%，97%有效）和18/275（6.5%，91%有效）。这明显低于未治疗组或接种组的患病率（P < 0.001）。与每3周进行1 h的足浴相比，每周足浴的病羊显著减少（P < 0.05）。接种全细胞疫苗或重组疫苗均显著（P < 0.001）降低了患病率(分别为142/280（51%，有效33%）和114/278(41%，有效46%)，重组疫苗优于全细胞疫苗（P < 0.05）。1岁龄羊的足步率显著低于老年羊（P < 0.05）。单次治疗将患病率降低至12%(53/445)，而未经治疗的绵羊患病率为57%(27/47)（79%有效）。结论足疗比预防接种更能有效地控制和治疗多菌种足癣。
Objective Compare footbathing and vaccination for control of footrot during a transmission period in a sheep flock deliberately infected with multiple strains of Dichelobacter nodosus. Methods The strains included a known virulent strain, a benign strain and several intermediate strains. The resulting footrot was clinically intermediate. A total of 1450 Polwarth sheep aged 1-3 years were allocated to one of five treatment groups: untreated, weekly walkthrough zinc sulfate footbathing, 1-hour stand-in Footrite (R) footbathing every 3 weeks, vaccination with a commercial multivalent whole-cell vaccine and vaccination with a novel recombinant DNA fimbrial vaccine. There were four replicates, in four paddocks. Results Of the untreated animals, 76% had footrot. Footbathing, either weekly or every 3 weeks, restricted the prevalence to 6/283 (2%; 97% effective) and 18/275 (6.5%; 91% effective), respectively. This was significantly lower than the prevalence in either the untreated or vaccinated group (P < 0.001). Weekly footbathing resulted in significantly fewer affected sheep than footbathing for 1 h every 3 weeks (P < 0.05). Vaccination with either whole-cell or recombinant vaccines significantly (P < 0.001) reduced the prevalence ((142/280 (51%; 33% effective), 114/278 (41%; 46% effective) respectively), with the recombinant vaccine superior (P < 0.05) to whole-cell vaccination. Significantly (P < 0.05) fewer 1-year-old sheep had footrot than older sheep. A single Footrite treatment reduced the prevalence to 12% (53/445) compared with a prevalence of 57% (27/47) for untreated sheep (79% effective). Conclusion In this study footbathing was more effective than vaccination at controlling and treating multistrain footrot.