Spatial memory extinction: A c-Fos protein mapping study
Spatial memory extinction: A c-Fos protein mapping study
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DOI：
10.1016/j.bbr.2013.11.032
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发表时间：
2014-03-01
影响因子：
2.7
通讯作者：
Arias, J. L.
中科院分区：
文献类型：
--
作者：
Mendez-Couz, M.;Conejo, N. M.;Arias, J. L.
虽然空间记忆巩固的神经基础已被彻底研究，介导的消退过程的基板仍然在很大程度上未知。本研究的目的是评估在Morris水迷宫中，在先前获得的空间记忆任务消退过程中，所选脑区的功能贡献。为此，我们使用了成年雄性Wistar大鼠在空间参考记忆任务的训练。在皮质和皮质下区域的c-Fos免疫反应细胞训练后的学习相关的变化进行了评估。结果表明，在水迷宫中移除隐藏的平台诱导了16次试验后先前增强的逃避行为的消退，24 h后没有自发恢复。灭绝与杏仁核和前额叶皮质中c-Fos阳性核团的数量显著增加有关。另一方面，外侧乳头体显示出比对照组更多的c-Fos阳性细胞。因此，与经典条件反射的研究结果相比，我们表明间脑结构介导这种学习的参与。总之，我们的研究结果表明，内侧前额叶皮层，杏仁核复合体和间脑结构，如外侧乳头核与空间记忆的消退有关。(C)2013爱思唯尔有限公司版权所有。
While the neuronal basis of spatial memory consolidation has been thoroughly studied, the substrates mediating the process of extinction remain largely unknown. This study aimed to evaluate the functional contribution of selected brain regions during the extinction of a previously acquired spatial memory task in the Morris water maze. For that purpose, we used adult male Wistar rats trained in a spatial reference memory task. Learning-related changes in c-Fos inmunoreactive cells after training were evaluated in cortical and subcortical regions. Results show that removal of the hidden platform in the water maze induced extinction of the previously reinforced escape behavior after 16 trials, without spontaneous recovery 24 h later. Extinction was related with significantly higher numbers of c-Fos positive nuclei in amygdala nuclei and prefrontal cortex. On the other hand, the lateral mammillary bodies showed higher number of c-Fos positive cells than the control group. Therefore, in contrast with the results obtained in studies of classical conditioning, we show the involvement of diencephalic structures mediating this kind of learning. In summary, our findings suggest that medial prefrontal cortex, the amygdala complex and diencephalic structures like the lateral mammillary nuclei are relevant for the extinction of spatial memory. (C) 2013 Elsevier B.V. All rights reserved.