12-MONTH AND 24-MONTH NEUROBEHAVIOURAL FOLLOW-UP OF CHILDREN PRENATALLY EXPOSED TO MARIHUANA, CIGARETTES AND ALCOHOL
12-MONTH AND 24-MONTH NEUROBEHAVIOURAL FOLLOW-UP OF CHILDREN PRENATALLY EXPOSED TO MARIHUANA, CIGARETTES AND ALCOHOL
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DOI：
10.1016/0892-0362(88)90032-3
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发表时间：
1988-07-01
影响因子：
2.9
通讯作者：
WATKINSON, B
中科院分区：
文献类型：
--
作者：
FRIED, PA;WATKINSON, B
对217名12个月大的婴儿和153名24个月大的婴儿进行了运动、智力和语言发展以及家庭环境的检查，这些婴儿在产前接触过大麻、酒精和香烟。对于这种低风险样本，采用多元回归分析来评估结果测量与产前药物暴露之间的关系，同时调整潜在的混杂因素。产前接触大麻与一系列评估儿童态度和兴趣的项目有独特的正相关，这些项目反映了认知因素。在24个月大时，适度饮酒与较低的智力得分显著相关。产前母亲吸烟与12个月时较低的智力得分以及12和24个月时对听觉项目的反应改变显著相关。然而，在24个月时，产后环境因素与认知结果和产前母亲吸烟的强烈关系导致母亲吸烟的显著、独特的预测能力丧失。基于目前的工作，并辅以先前报告的有关怀孕期间孕产妇态度和新生儿行为的数据，提出了一种事务性解释。
The motor, mental, and language development plus the home environment was examined in 217 twelve-month and 153 twenty-four-month-old children for whom prenatal exposure to marihuana, alcohol and cigarettes was previously ascertained. With this low-risk sample multiple regression analysis was used to assess the association between outcome measures nad prenatal drug exposure while adjusting for potential confounding factors. Prenatal exposure to marihuana was uniquely positively associated with a series of items evaluating the child''s attitudes and interests that reflect a cognitive factor. Moderate levels of alcohol were significantly associated with lower mental scores at 24 months of age. Prenatal maternal cigarette smoking was significantly associated with lower mental scores at 12 months of age and altered responses on auditory items at 12 and 24 months. However, at 24 months, the strong relationship of postnatal environmental factors with cognitive outcomes and with prenatal maternal smoking resulted in loss of significant, unique predictive power for maternal smoking. Based on the present work and supplemented by previously reported data pertaining to maternal attitudes during pregnancy and neonatal behaviour, a transactional interpretation is presented.