Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children
Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children
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DOI：
10.1007/s00247-011-2071-x
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发表时间：
2011-08-01
影响因子：
2.3
通讯作者：
Haataja, Leena
中科院分区：
文献类型：
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作者：
Lind, Annika;Parkkola, Riitta;Haataja, Leena
早产儿脑容量的改变以及脑容量与发育结果之间的关系已被报道。评估无神经发育障碍（[NDI]脑瘫、听力损失、失明和认知能力明显延迟）的极低出生体重（VLBW）儿童与有NDI的VLBW儿童相比，哪些区域脑容量不同，并评估足期等值年龄区域脑容量与矫正2岁时认知发育和神经功能表现之间的关系。研究组由164名VLBW儿童组成的区域队列，分为无NDI儿童组（n = 148）和有NDI儿童组（n = 16）。脑（MRI）在学期等效年龄进行，从中手动分析脑容量。使用Bayley婴儿发育量表II （BSID-II）评估认知发展，并在矫正年龄2岁时使用Hammersmith婴儿神经学检查评估神经功能。NDI患儿的脑组织体积、大脑体积、额叶体积、基底节区体积、丘脑体积和小脑体积明显小于非NDI患儿，脑室体积明显大于非NDI患儿。即使在没有NDI的儿童中，较小的小脑体积与矫正年龄2岁时较差的神经功能显著相关。脑MRI体积分析可以为早期预测VLBW儿童的预后提供额外的参数。
Altered brain volumes and associations between volumes and developmental outcomes have been reported in prematurely born children.To assess which regional brain volumes are different in very low birth weight (VLBW) children without neurodevelopmental impairments ([NDI] cerebral palsy, hearing loss, blindness and significantly delayed cognitive performance) compared with VLBW children with NDI, and to evaluate the association between regional brain volumes at term-equivalent age and cognitive development and neurological performance at a corrected age of 2 years.The study group consisted of a regional cohort of 164 VLBW children, divided into one group of children without NDI (n = 148) and one group of children with NDI (n = 16). Brain (MRI) was performed at term-equivalent age, from which brain volumes were manually analysed. Cognitive development was assessed with the Bayley Scales of Infant Development II (BSID-II), and neurological performance with the Hammersmith Infant Neurological Examination at the corrected age of 2 years.The volumes of total brain tissue, cerebrum, frontal lobes, basal ganglia and thalami, and cerebellum were significantly smaller, and the volume of the ventricles significantly larger, in the children with NDI than in those without NDI. Even in children without NDI, a smaller cerebellar volume was significantly correlated with poor neurological performance at 2 years of corrected age.Volumetric analysis at brain MRI can provide an additional parameter for early prediction of outcome in VLBW children.