Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists
Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists
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DOI：
10.1021/acs.jmedchem.5b01394
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发表时间：
2015-10-22
影响因子：
7.3
通讯作者：
Biggin, Philip C.
中科院分区：
文献类型：
--
作者：
Heifetz, Alexander;Bodkin, Mike J.;Biggin, Philip C.
在本期中，Nagase及其同事报告了第一个选择性非肽类食欲素2受体（OX2R）激动剂的发现。这些OX2R选择性激动剂的发现为与食欲素系统的激活相关的疗法开辟了新的途径，特别是关于治疗睡眠障碍如发作性睡病。
In this issue, Nagase and colleagues report the discovery of the first selective nonpeptidic orexin 2 receptor (OX2R) agonists. The discovery of these OX2R selective agonists opens up new avenues for therapies related to the activation of the orexin system, especially with respect to the treatment of sleep disorders such as narcolepsy.