Male-predominant galanin mediates androgen-dependent aggressive chases in medaka
Male-predominant galanin mediates androgen-dependent aggressive chases in medaka
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DOI：
10.7554/elife.59470
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发表时间：
2020-08
期刊：
影响因子：
7.7
通讯作者：
J. Yamashita;A. Takeuchi;Kohei Hosono;T. Fleming;Y. Nagahama;K. Okubo
中科院分区：
文献类型：
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作者：
J. Yamashita;A. Takeuchi;Kohei Hosono;T. Fleming;Y. Nagahama;K. Okubo
最近在小鼠身上的研究表明，内侧视前区(MPOA)中表达甘丙素的一部分神经元在调节两性父母的行为方面发挥了关键作用。然而，关于甘丙素在其他物种的社会行为中的作用的信息很少。在这里，我们报告，在青竹，MPOA甘丙素神经元的一个子集几乎只出现在男性，由睾丸雄激素刺激引起。缺乏甘丙素的青竹表明，男性和男性之间的攻击性追逐的发生率大大降低。此外，虽然用雄激素治疗雌性青竹会引起男性典型的攻击行为，但这些雌性青蛙体内甘丙素缺乏会减弱雄激素对Chase的影响。鉴于其偏向男性和雄激素依赖的性质，MPOA甘丙素神经元的亚群很可能介导雄激素依赖的雄-雄追逐。组织学研究进一步表明，MPOA Galanin神经元投射靶点的可变性可能解释了这些进化上保守的神经底物的物种依赖功能差异。
Recent studies in mice demonstrate that a subset of neurons in the medial preoptic area (MPOA) that express galanin play crucial roles in regulating parental behavior in both sexes. However, little information is available on the function of galanin in social behaviors in other species. Here, we report that, in medaka, a subset of MPOA galanin neurons occurred nearly exclusively in males, resulting from testicular androgen stimulation. Galanin-deficient medaka showed a greatly reduced incidence of male–male aggressive chases. Furthermore, while treatment of female medaka with androgen induced male-typical aggressive acts, galanin deficiency in these females attenuated the effect of androgen on chases. Given their male-biased and androgen-dependent nature, the subset of MPOA galanin neurons most likely mediate androgen-dependent male–male chases. Histological studies further suggested that variability in the projection targets of the MPOA galanin neurons may account for the species-dependent functional differences in these evolutionarily conserved neural substrates.