Convergence of linear acceleration and yaw rotation signals on non-eye movement neurons in the vestibular nucleus of macaques.
Convergence of linear acceleration and yaw rotation signals on non-eye movement neurons in the vestibular nucleus of macaques.
复制标题
猕猴前庭核非眼动神经元线性加速度和偏航旋转信号的收敛。
DOI：
10.1152/jn.00382.2017
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Luan,Hongge
中科院分区：
文献类型：
--
作者：
Newlands,ShawnD;Abbatematteo,Ben;Wei,Min;Carney,LaurelH;Luan,Hongge
在所有没有眼动敏感性的前庭核神经元中，大约有一半对角旋转和线性加速都有反应。线性加速信号来自耳石器官，旋转信号来自半规管。在前庭神经中，这些信号由不同的传入神经传递。前庭核神经元是这些不同感觉信号的第一个汇聚点。本研究系统地评估了前庭核单个神经元中旋转和动信号的相互作用：在这两个独立的前庭感觉信号第一次汇聚时的多感觉整合。对清醒猕猴的前庭核进行单单元记录，包括偏航旋转、水平面平移以及不同频率的旋转和平移组合。平移和旋转组合的总体反应幅度通常小于单独施加刺激的反应幅度之和。然而，我们发现在旋转和动响应峰重合的条件下，这些信号近似是可加的。在不同频率下呈现旋转和平移时，无论是在较高频率下，旋转都比和平移衰减得更大。这些数据表明，前庭核中这两种感觉模式之间存在非线性相互作用，其中一致的峰值反应成比例地强于其他非峰值相互作用。这些结果类似于其他形式的多感觉整合，如上丘的视听整合。这是第一个通过独立操作系统地探索前庭核旋转和动信号相互作用的研究。研究结果表明，当峰值旋转和平移响应的时间和方向一致时，非线性积分导致响应幅值最大。
Roughly half of all vestibular nucleus neurons without eye movement sensitivity respond to both angular rotation and linear acceleration. Linear acceleration signals arise from otolith organs, and rotation signals arise from semicircular canals. In the vestibular nerve, these signals are carried by different afferents. Vestibular nucleus neurons represent the first point of convergence for these distinct sensory signals. This study systematically evaluated how rotational and translational signals interact in single neurons in the vestibular nuclei: multisensory integration at the first opportunity for convergence between these two independent vestibular sensory signals. Single-unit recordings were made from the vestibular nuclei of awake macaques during yaw rotation, translation in the horizontal plane, and combinations of rotation and translation at different frequencies. The overall response magnitude of the combined translation and rotation was generally less than the sum of the magnitudes in responses to the stimuli applied independently. However, we found that under conditions in which the peaks of the rotational and translational responses were coincident these signals were approximately additive. With presentation of rotation and translation at different frequencies, rotation was attenuated more than translation, regardless of which was at a higher frequency. These data suggest a nonlinear interaction between these two sensory modalities in the vestibular nuclei, in which coincident peak responses are proportionally stronger than other, off-peak interactions. These results are similar to those reported for other forms of multisensory integration, such as audio-visual integration in the superior colliculus.NEW & NOTEWORTHYThis is the first study to systematically explore the interaction of rotational and translational signals in the vestibular nuclei through independent manipulation. The results of this study demonstrate nonlinear integration leading to maximum response amplitude when the timing and direction of peak rotational and translational responses are coincident.