Effects of lung volume on clearance of solutes from the air spaces of lungs.
Effects of lung volume on clearance of solutes from the air spaces of lungs.
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肺容量对肺部空气空间中溶质清除的影响。
DOI：
10.1152/jappl.1988.64.3.1068
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
McLarty,JW
中科院分区：
文献类型：
--
作者：
Peterson,BT;James,HL;McLarty,JW
一些研究者已经表明，99 mTc标记的二亚乙基三胺五乙酸酯（DTPA，mol wt = 492，半径= 0.6 nm）从人和实验动物的肺的空气空间的气溶胶化的清除率随着肺体积而增加。为了进一步研究这一现象，我们使用一种新方法对麻醉绵羊肺中DTPA的2小时清除率进行了房室分析，以更准确地校正DTPA再循环的影响。该分析表明，在8只绵羊中，零呼气末压力通气的DTPA清除率最好用一室模型描述，清除率为0.42 ± 0.15%/min。在整个研究中，8只绵羊以10 cmH 2 O呼气末压力通气，呼气末容量增加0.4 ± 0.1升BTPS，并创建了最好用二室模型描述的清除率曲线。分室模型在这些绵羊中，56 ± 16%的DTPA以7.9 ± 2.9%/min的速率从肺中清除。其余的清除速率与在零呼气末压力通气的绵羊中测量的速率相似（0.35 ± 0.18%/min）。使用99 mTc标记的人血清白蛋白（mol wt = 66，000，半径= 3.6 nm）进行额外的对照和肺膨胀实验。在6只对照绵羊中，零呼气末压通气，白蛋白清除率最好用一室模型描述，清除率为0.06 ± 0.02%/min。在6只肺容量增加的绵羊中，清除率略高（0.09 ± 0.02，P <0.05），但一室模型描述良好。（250字处删节）
Several investigators have shown that the clearance rate of aerosolized 99mTc-labeled diethylenetriamine pentaacetate (DTPA, mol wt = 492, radius = 0.6 nm) from the air spaces of the lungs of humans and experimental animals increases with lung volume. To further investigate this phenomenon we performed a compartmental analysis of the 2-h clearance of DTPA from the lungs of anesthetized sheep using a new method to more accurately correct for the effects of DTPA recirculation. This analysis showed that the DTPA clearance in eight sheep ventilated with zero end-expired pressure was best described by a one-compartment model with a clearance rate of 0.42 ± 0.15%/min. Ventilating eight sheep with an end-expired pressure of 10 cmH2O throughout the study increased the end-expired volume 0.4 ± 0.1 liter BTPS and created a clearance curve that was best described by a two-compartment model. In these sheep 56 ± 16% of the DTPA cleared from the lungs at a rate of 7.9 ± 2.9%/min. The remainder cleared at a rate similar to that measured in the sheep ventilated with zero end-expired pressure (0.35 ± 0.18%/min). Additional control and lung inflation experiments were performed using 99mTc-labeled human serum albumin (mol wt = 66,000, radius = 3.6 nm). In six control sheep ventilated with zero end-expired pressure the albumin clearance was best described by a one-compartment model with a clearance rate of 0.06 ± 0.02%/min. The clearance rate in six sheep with increased lung volume was slightly larger (0.09 ± 0.02, P less than 0.05) but was well described by a one-compartment model.(ABSTRACT TRUNCATED AT 250 WORDS)