Organophotoredox and Hydrogen Atom Transfer Cocatalyzed C–H Alkylation of Quinoxalin-2(1H)-ones with Aldehydes, Amides, Alcohols, Ethers, or Cycloalkanes
Organophotoredox and Hydrogen Atom Transfer Cocatalyzed C–H Alkylation of Quinoxalin-2(1H)-ones with Aldehydes, Amides, Alcohols, Ethers, or Cycloalkanes
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有机光氧化还原和氢原子转移助催化喹喔啉-2(1H)-酮与醛、酰胺、醇、醚或环烷烃的 C–H 烷基化
DOI：
10.1021/acs.joc.2c01967
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Peijun Liu
中科院分区：
文献类型：
--
作者：
Liling Wang;Zhaoxing Chen;Guohua Fan;Xiaozu Liu;Peijun Liu
描述了一种温和的方法，其将有机光氧化还原催化与氢原子转移合并，以使喹喔啉-2（1H）-酮与原料醛、酰胺、醇、醚或环烷烃的C-H烷基化。该反应在环境友好且无外部氧化剂的反应条件下发生，提供了获得具有广泛取代基多样性和良好官能团相容性的各种C3-烷基化喹喔啉酮衍生物的通用且可持续的途径。
Described is a mild method that merges organophotoredox catalysis with hydrogen atom transfer to enable C–H alkylation of quinoxalin-2(1H)-ones with feedstock aldehydes, amides, alcohols, ethers, or cycloalkanes. This reaction occurred under environmentally benign and external oxidant-free reaction conditions, providing a general and sustainable access to various C3-alkylated quinoxalinone derivatives with broad substituent diversity and good functional group compatibility.