Exposure to domoic acid through shellfish consumption in Belgium
Exposure to domoic acid through shellfish consumption in Belgium
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DOI：
10.1016/j.envint.2012.08.007
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发表时间：
2012-11-15
影响因子：
11.8
通讯作者：
Van Loco, J.
中科院分区：
文献类型：
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作者：
Andjelkovic, M.;Vandevijvere, S.;Van Loco, J.
已知的导致人类健忘症贝类中毒的主要罪魁祸首是软骨藻酸(DA)。密切监测海水中的毒素(通过计算产生毒素的藻类)以及贝类中的毒素，以防止出现胃肠道症状和神经体征的急性中毒。然而，据推测，在动物体内反复暴露于这种毒素可能存在一些慢性问题。在人类中，这一点是非常未知的，主要是通过联系报告的毒素事件和代表性的消费数据来评估的。虽然比利时近年来没有报告令人震惊的疫情，但在贝类样本中发现了不同浓度的DA。在这项研究中，通过将2004-2009年期间在国家食品控制计划范围内收集的样本中DA浓度的数据与比利时国家食品消费调查(包括3245名成年人)获得的消费数据联系起来，评估了人类通过贝类消费对DA的急性和慢性暴露。扇贝的毒素水平最高，贻贝的毒素水平最低。整个比利时人口对扇贝、贻贝和牡蛎等软体动物的平均长期摄入量为扇贝0.10克/天到贻贝1.21克/天。根据贝类来源的不同，平均份量估计为56-108克/天，据计算，只有不到1%的人口有急性中毒的风险。使用中等结合浓度的方法，5-6%的人群表现出慢性接触，超过每天0.075微克/公斤体重的容许摄入量，当使用较低(68.5%)和中等结合浓度(45.6%)的结合浓度时，扇贝是最有可能的毒素媒介。(C)2012爱思唯尔有限公司。保留所有权利。
A main known culprit causing amnesic shellfish poisoning in humans is domoic acid (DA). The toxin appearance in sea waters (by counting the toxin producing algae) and consequently in shellfish is closely monitored to prevent acute intoxications with gastrointestinal symptoms and neurological signs. However it is assumed that there might be some chronic problems with repetitive exposures to the toxin in animals. In humans this is greatly unknown and it is mostly assessed by relating reported toxin episodes and representative consumption data. Although in Belgium no alarming outbreaks have been reported in recent years, different concentrations of DA have been found in shellfish samples. In this study the human acute and chronic exposure to DA through shellfish consumption was evaluated by linking the data of DA concentrations in samples collected in the scope of the National Food control program in the period 2004-2009 and consumption data obtained from the National Belgian Food Consumption Survey including 3245 adults. The found level of toxin was highest in scallops while lowest in mussels. The mean usual long-term intake of molluscs such as scallops, mussels and oysters for the whole Belgian population was from 0.10 g/day for scallops to 1.21 g/day for mussels. With average portion size estimated to be 56-108 g/day depending on the shellfish source it was calculated that less than 1% of the population would be at risk of acute intoxication. Using a medium bound approach, 5-6% of the population shows chronic exposure exceeding the tolerable daily intake of 0.075 mu g/kg bw per day with scallops being the most probable toxin vector when using lower (68.5%) and medium (45.6%) bound concentrations. (C) 2012 Elsevier Ltd. All rights reserved.