Exploring phosphatidylinositol 5-phosphate 4-kinase function.
Exploring phosphatidylinositol 5-phosphate 4-kinase function.
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DOI：
10.1016/j.jbior.2014.09.007
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发表时间：
2015-01
影响因子：
--
通讯作者：
Irvine, Robin F
中科院分区：
文献类型：
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作者：
Bulley, Simon J;Clarke, Jonathan H;Droubi, Alaa;Giudici, Maria-Luisa;Irvine, Robin F
磷脂酰肌醇5-磷酸4-激酶（PI 5 P4 Ks）家族正从肌醇信号传导的相对停滞中出现，进入主流，其底物磷脂酰肌醇5-磷酸（PI 5 P）也是如此。在这里，我们回顾了一些关于PI 5 P4 Ks的关键问题，它们的定位，相互作用和调节，我们还总结了我们目前对PI 5 P如何合成及其细胞功能的理解。最后，一些参与病理学的PI 5 P4 Ks的证据进行了讨论。
The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.