Activation of oxytocinergic neurons enhances torpor in mice
Activation of oxytocinergic neurons enhances torpor in mice
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DOI：
10.1007/s00360-023-01528-y
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发表时间：
2024-01-03
影响因子：
2
通讯作者：
Swoap，Steven J.
中科院分区：
文献类型：
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作者：
Hare，Maia T.;Carter，Matthew E.;Swoap，Steven J.
小家鼠在亚热中性环境温度下对热量限制的反应是进入一种迟钝状态。这种迟钝状态的特征在于代谢率、心率、体温和活动的适应性和受控降低。先前的研究已经确定了下丘脑室旁核（PVN），一个含有催产素神经元的区域，作为一个在麻痹发作期间活跃的位置。我们假设室旁核内的催产素神经元是这个神经回路的一部分，催产素神经元的激活会加深和延长麻痹发作。我们报告说，催产素神经元单独激活是不足以诱导一个torpor-like状态在喂养的小鼠，催产素神经元激活后，体温或心率没有显着差异。然而，我们发现，在日常麻木开始之前，催产素神经元的激活会加深和延长随后的发作，体温降低1.7 ± 0.4 °C，长度增加135 ± 32分钟。因此，我们得出结论，催产素神经元参与了控制小鼠日常麻木的神经回路。
Mus musculusenters a torpid state in response to caloric restriction in sub-thermoneutral ambient temperatures. This torpid state is characterized by an adaptive and controlled decrease in metabolic rate, heart rate, body temperature, and activity. Previous research has identified the paraventricular nucleus (PVN) within the hypothalamus, a region containing oxytocin neurons, as a location that is active during torpor onset. We hypothesized that oxytocin neurons within the PVN are part of this neural circuit and that activation of oxytocin neurons would deepen and lengthen torpor bouts. We report that activation of oxytocin neurons alone is not sufficient to induce a torpor-like state in the fed mouse, with no significant difference in body temperature or heart rate upon activation of oxytocin neurons. However, we found that activation of oxytocin neurons prior to the onset of daily torpor both deepens and lengthens the subsequent bout, with a 1.7 ± 0.4 °C lower body temperature and a 135 ± 32 min increase in length. We therefore conclude that oxytocin neurons are involved in the neural circuitry controlling daily torpor in the mouse.