Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease
Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease
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DOI：
10.1016/j.neuroimage.2010.03.005
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Hilker, Ruediger
中科院分区：
文献类型：
--
作者：
Baudrexel, Simon;Nuernberger, Lucas;Hilker, Ruediger
定量磁共振成像是一种很有前途的活体成像技术，它基于对物理组织参数的测定，揭示了神经退行性疾病中大脑形态的不同方面。采用T1和T2*图相结合的方法，观察了20例早期帕金森病(PD)患者和20例健康对照组的中脑和下脑干局部松弛时间的变化。Voxelise统计参数图显示，临床上受影响更严重的肢体对侧的中脑T1值普遍降低。在SN内，T1的降低与各种身体研究中所检测到的选择性神经元丢失的已知模式相匹配，表明T1是PD相关组织病理的标志。然而，T1降低的空间范围超过了SN，到达了桥脑交界处的非多巴胺能区，可能与早期帕金森病的非运动症状有关。相反，T2*图显示仅限于SN的T2*值的双侧降低，表明局部总铁含量增加。我们的结论是，尤其是在纵向研究中，定量T1可能是监测帕金森病患者进行性神经元丢失的一个有价值的标记，而黑质T2*的减少可能与疾病发展的一般易感性增加更密切相关。(C)2010 Elsevier Inc.保留所有权利。
Quantitative magnetic resonance imaging is a promising in vivo imaging technique revealing insights into different aspects of brain morphology in neurodegenerative diseases based on the determination of physical tissue parameters. Using combined T1- and T2*-mapping, we investigated changes of local relaxation times in the midbrain and lower brainstem of 20 patients with early Parkinson's disease (PD) compared to 20 healthy controls. Voxelwise statistical parametric mapping disclosed a widespread reduction of midbrain T1 values contralateral to the clinically more severely affected limbs. Within the SN, the T1 decrease matched the known pattern of selective neuronal loss as examined in various post-mortem studies, suggesting that T1 is a marker for PD related tissue pathology. However, the spatial extent of T1 reductions exceeded the SN and reached non-dopaminergic areas in the pontomesencephalic junction potentially involved in early non-motor symptoms of PD. In contrast, T2*-mapping revealed a bilateral decrease of T2* values restricted to the SN, indicating a local increase in total iron content. We conclude that, particularly in longitudinal studies, quantitative T1 may be a valuable marker for the monitoring of progressive neuronal loss in PD, whereas nigral T2* reductions might be more closely associated with an increased general vulnerability for the development of the disorder. (C) 2010 Elsevier Inc. All rights reserved.