Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density.
Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density.
复制标题
叶黄素、玉米黄质和内消旋玉米黄质补充剂与黄斑色素光密度相关
DOI：
10.3390/nu8070426
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发表时间：
2016-07-12
期刊：
影响因子：
5.9
通讯作者：
Liu XH
中科院分区：
文献类型：
--
作者：
Ma L;Liu R;Du JH;Liu T;Wu SS;Liu XH
本研究的目的是在年龄相关性黄斑变性（AMD）患者和健康受试者中进行随机对照试验（RCT），以评估叶黄素、玉米黄质和meso-zeaxanthin对黄斑色素光密度（MPOD）的影响。检索了Medline、Embase、Web of Science和科克伦图书馆数据库，截止日期为2016年5月。对干预组和安慰剂组的基线和终点MPOD变化进行Meta分析，以获得校正的加权平均差异（WMD）。Pearson相关分析用于确定MPOD变化与血液叶黄素类胡萝卜素或基线MPOD水平之间的关系。确定了20项RCT，涉及938名AMD患者和826名健康受试者。补充叶黄素类胡萝卜素与AMD患者（WMD，0.07; 95%CI，0.03至0.11）和健康受试者（WMD，0.09; 95%CI，0.05至0.14）的MPOD显著增加相关。分层分析表明，在补充和结合内消旋玉米黄质的试验中，MPOD有更大的增加。此外，MPOD的变化与基线MPOD水平（rAMD =-0.43，p = 0.06; r健康受试者=-0.71，p < 0.001）和血液叶黄素类胡萝卜素浓度（rAMD = 0.40，p = 0.07; r健康受试者= 0.33，p = 0.05）相关。该荟萃分析显示，叶黄素、玉米黄质和内消旋玉米黄质补充剂改善了AMD患者和健康受试者的MPOD，并具有剂量-反应关系。
The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigment optical density (MPOD) in randomized controlled trials (RCTs) among patients with age-related macular degeneration (AMD) and healthy subjects. Medline, Embase, Web of Science and Cochrane Library databases was searched through May 2016. Meta-analysis was conducted to obtain adjusted weighted mean differences (WMD) for intervention-versus-placebo group about the change of MPOD between baseline and terminal point. Pearson correlation analysis was used to determine the relationship between the changes in MPOD and blood xanthophyll carotenoids or baseline MPOD levels. Twenty RCTs involving 938 AMD patients and 826 healthy subjects were identified. Xanthophyll carotenoids supplementation was associated with significant increase in MPOD in AMD patients (WMD, 0.07; 95% CI, 0.03 to 0.11) and healthy subjects (WMD, 0.09; 95% CI, 0.05 to 0.14). Stratified analysis showed a greater increase in MPOD among trials supplemented and combined with meso-zeaxanthin. Additionally, the changes in MPOD were related with baseline MPOD levels (rAMD = −0.43, p = 0.06; rhealthy subjects = −0.71, p < 0.001) and blood xanthophyll carotenoids concentration (rAMD = 0.40, p = 0.07; rhealthy subjects = 0.33, p = 0.05). This meta-analysis revealed that lutein, zeaxanthin and meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy subjects with a dose-response relationship.