An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit
An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit
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DOI：
10.1016/j.oraloncology.2004.02.005
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发表时间：
2004-09-01
期刊：
影响因子：
4.8
通讯作者：
Porter, SR
中科院分区：
文献类型：
--
作者：
Poate, TWJ;Buchanan, JAG;Porter, SR
口腔上皮的诊断。发育异常传统上是基于对来自病变组织的全层活检标本的组织病理学评价。最近有人提出，“刷检”样本的细胞学检查是一种非侵入性的方法，可以确定是否存在细胞增生，从而确定口腔上皮的可能性。发育不良本审计确定，回顾性的敏感性，特异性和阳性和阴性预测值的口腔刷活检技术在诊断潜在的恶性疾病在一组112名患者参加专科口腔医学单位。口腔刷检系统对口腔上皮异常增生或鳞状细胞癌检出的敏感性为71.4%，特异性为32%。异常刷检结果（阳性或非典型）的阳性预测值为44.1%，而阴性预测值为60%。结论是，并非所有。通过这种非侵入性的调查程序可以发现潜在的恶性疾病。(C)2004 Elsevier Ltd.保留所有权利。
The diagnosis of oral epithelial. dysplasia has traditionally been based upon histopathological evaluation of a full thickness biopsy specimen from lesional tissue. It has recently been proposed that cytological examination of "brush biopsy" samples is a non-invasive method of determining the presence of cellular atypia, and hence the likelihood of oral epithelial. dysplasia. The present audit determined, retrospectively the sensitivity, specificity and positive and negative predictive values of the oral brush biopsy technique in the diagnosis of potentially malignant disease in a group of 112 patients attending a specialist Oral Medicine unit. The sensitivity of detection of oral epithelial dysplasia or squamous cell carcinoma of the oral brush biopsy system was 71.4% while the specificity was 32%. The positive predictive value of an abnormal brush biopsy result (positive or atypical) was 44.1%, while the negative predictive value was 60%. It is concluded that not all. potentially malignant disease is detected with this non-invasive investigative procedure. (C) 2004 Elsevier Ltd. All rights reserved.