Operant Conditioning of Primate Prefrontal Neurons
Operant Conditioning of Primate Prefrontal Neurons
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DOI：
10.1152/jn.00173.2009
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Sakagami, Masamichi
中科院分区：
文献类型：
--
作者：
Kobayashi, Shunsuke;Schultz, Wolfram;Sakagami, Masamichi
作者：小林S，Schultz W，Sakagami M.灵长类前额叶神经元的操作性条件反射。神经生理学杂志103：1843-1855，2010年。首次发表于2010年1月27日; doi：10.1152/jn.00173.2009。操作行为是对环境产生影响并产生结果的行为，是自愿行为的重要组成部分。因为环境可能是不稳定的，同样的行动可能会导致不同的后果。因此，为了获得最佳结果，检测行动与结果的关系并相应地调整行为至关重要。虽然前额叶神经元的活动取决于预期的奖励，但前额叶活动是否有助于获得奖励仍然是未知的。我们通过设置单神经元活动水平和奖励结果之间的变量关系来研究这个问题。外侧前额叶神经元根据获得奖励的特定要求改变其尖峰活动，而动物不做出运动反应。因此，尖峰活动构成了一种操作性反应。来自控制任务的数据表明，这些变化不太可能反映简单的奖励预测。这些数据表明，前额叶神经元的显着能力，以适应特定的操作性要求在单神经元水平。
Kobayashi S, Schultz W, Sakagami M. Operant conditioning of primate prefrontal neurons. J Neurophysiol 103: 1843-1855, 2010. First published January 27, 2010; doi: 10.1152/jn.00173.2009. An operant is a behavioral act that has an impact on the environment to produce an outcome, constituting an important component of voluntary behavior. Because the environment can be volatile, the same action may cause different consequences. Thus to obtain an optimal outcome, it is crucial to detect action-outcome relationships and adapt the behavior accordingly. Although prefrontal neurons are known to change activity depending on expected reward, it remains unknown whether prefrontal activity contributes to obtaining reward. We investigated this issue by setting variable relationships between levels of single-neuron activity and rewarding outcomes. Lateral prefrontal neurons changed their spiking activity according to the specific requirements for gaining reward, without the animals making a motor response. Thus spiking activity constituted an operant response. Data from a control task suggested that these changes were unlikely to reflect simple reward predictions. These data demonstrate a remarkable capacity of prefrontal neurons to adapt to specific operant requirements at the single-neuron level.