3D Blood Flow Characteristics in the Carotid Artery Bifurcation Assessed by Flow-Sensitive 4D MRI at 3T
3D Blood Flow Characteristics in the Carotid Artery Bifurcation Assessed by Flow-Sensitive 4D MRI at 3T
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DOI：
10.1002/mrm.21774
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Harloff, A.;Albrecht, F.;Markl, M.
为了确定颈动脉分叉处的三维（3D）血流模式，10名健康志愿者和9名颈内动脉（伊卡）狭窄>= 50%的患者在3 T下进行了流量敏感的4D MRI检查。通过双功超声（DS）测量颈总动脉（CCA）的绝对和平均血流速度、搏动指数（PI）和阻力指数（RI），并与血流敏感性4D MRI进行比较。此外，再通前后志愿者和患者颈动脉分叉处的3D MRI血流模式由两名独立的阅片者进行分级。通过MRI测量的血流速度比DS低31-39%。然而，PI和RI仅相差13- 16%。伊卡的3D血流特征评级显示志愿者的充盈和螺旋流模式一致。在伊卡狭窄的患者中，3D血流可视化成功地用于检测伊卡球中显著改变的充盈和螺旋流模式（向前移动的螺旋流），并评估重建血管的效果，恢复充盈和螺旋流。我们的研究结果表明，流动敏感的4D磁共振成像的量化和三维可视化的生理和病理流模式在颈动脉分叉的可行性。Magn Reson Mad 61：65-74，2009. (C)2008威利利斯公司
To determine three-dimensional (3D) blood flow patterns in the carotid bifurcation, 10 healthy volunteers and nine patients with internal carotid artery (ICA) stenosis >= 50% were examined by flow-sensitive 4D MRI at 3T. Absolute and mean blood velocities, pulsatility index (PI), and resistance index (RI) were measured in the common carotid arteries (CCAs) by duplex sonography (DS) and compared with flow-sensitive 4D MRI. Furthermore, 3D MRI blood flow patterns in the carotid bifurcation of volunteers and patients before and after recanalization were graded by two independent readers. Blood flow velocities measured by MRI were 31-39% lower than in DS. However, PI and RI differed by only 13-16%. Rating of 3D flow characteristics in the ICA revealed consistent patterns for filling and helical flow in volunteers. In patients with ICA stenosis, 3D blood flow visualization was successfully employed to detect markedly altered filling and helical flow patterns (forward-moving spiral flow) in the ICA bulb and to evaluate the effect of revascularlzation, which restored filling and helical flow. Our results demonstrate the feasibility of flow-sensitive 4D MRI for the quantification and 3D visualization of physiological and pathological flow patterns in the carotid artery bifurcation. Magn Reson Mad 61:65-74, 2009. (C) 2008 Wiley-Liss, Inc.