Considering intellectual, in addition to financial, conflicts of interest proved important in a clinical practice guideline: a descriptive study
Considering intellectual, in addition to financial, conflicts of interest proved important in a clinical practice guideline: a descriptive study
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DOI：
10.1016/j.jclinepi.2014.05.006
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发表时间：
2014-11-01
影响因子：
7.2
通讯作者：
Guyatt, Gordon H.
中科院分区：
文献类型：
--
作者：
Akl, Elie A.;El-Hachem, Pierre;Guyatt, Gordon H.
目的：美国胸科医师学会抗血栓指南第九次迭代对小组成员的建议进行了限制，他们披露了主要利益冲突（COI）。我们的目的是描述小组成员的财务和智力COI和评估在何种程度上，除了评估财务COI，评估智力COI影响COI management.Study设计和设置：我们将财务和智力COI分为主要（原因投票限制）和次要（无限制）。结果：102名专家对431条建议进行了4,030次披露。每项建议中披露不同类别COI的小组成员的中位数（和范围）为：主要财务COI为0（0-5），次要财务COI为0（0-4），主要智力COI为0（0-7），次要智力COI为1（0-6）。在431项建议中，63项（15%）至少有一项pancreatitis与主要的智力COI，但没有主要的财务COI.Conclusion：COI有一个相对较低的患病率和偏态分布，许多小组成员没有和一些许多披露。在没有财务COI的情况下，大量披露本应导致基于知识COI的限制。(C)2014爱思唯尔公司All rights reserved.
Objectives: The American College of Chest Physicians Antithrombotic Guidelines ninth iteration placed restrictions on panelists with recommendations on which they disclosed a primary conflict of interest (COI). We aimed to describe panelists' financial and intellectual COI and evaluate to what extent, beyond assessing financial COI, assessing intellectual COI affected COI management.Study Design and Setting: We classified financial and intellectual COI into primary (causes voting restriction) and secondary (no restrictions). We analyzed disclosures respectively with panelists and recommendations as units of analysis.Results: One hundred two panelists made 4,030 disclosures for 431 recommendations. The median number (and range) of panelists per recommendation who disclosed the various categories of COI was 0 (0-5) for primary financial COI, 0 (0-4) for secondary financial COI, 0 (0-7) for primary intellectual COI, and 1(0-6) for secondary intellectual COI. Of the 431 recommendations, 63 (15%) had at least one panelist with a primary intellectual COI but no primary financial COI.Conclusion: COI had a relatively low prevalence and a skewed distribution, many panelists with none and some with many disclosures. A substantial number of disclosures should have resulted in restrictions based on intellectual COI in the absence of financial COI. (C) 2014 Elsevier Inc. All rights reserved.