18-fluoro-2-deoxyglucose positron emission tomography in detecting residual/recurrent nasopharyngeal carcinomas and comparison with magnetic resonance imaging
18-fluoro-2-deoxyglucose positron emission tomography in detecting residual/recurrent nasopharyngeal carcinomas and comparison with magnetic resonance imaging
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作者：
Yen, RF;Hung, RL;Kao, CH
背景。众所周知，18-氟-2-脱氧葡萄糖正电子发射断层扫描（FDG-PET）可有效早期发现残留/复发鼻咽癌（NPC）。为了比较 FDG-PET 与传统磁共振成像 (MRI) 检测残留/复发性鼻咽癌的效果，作者研究了 67 名鼻咽癌患者的随访病例，同时使用了 FDG-PET 和 MRI。方法。从1997年2月到2001年2月，招募了67名鼻咽癌患者（14名女性，53名男性；年龄范围，16-67岁；平均年龄，46.6+/-12.5岁）。每位患者的头颈部 FDG-PET 和 MRI 均在放疗或放疗同步化疗后至少 4 个月（持续时间范围 4-70 个月；平均 14 +/- 13.5 个月）进行。最终诊断由活检或至少 6 个月的临床随访证实。 结果。 FDG-PET图像的敏感性、特异性、准确性、阳性预测值(PPV)和阴性预测值(NPV)分别为100%、93.4%、95.5%、87.5%和100%。相比之下，MRI 扫描的敏感性、特异性、准确性、PPV 和 NPV 分别为 61.9%、43.5%、49.3%、33.3% 和 70.0%。结论。目前的研究结果表明，FDG-PET 在检测残留/复发性鼻咽癌方面比 MRI 更有效。 (C) 2003 年美国癌症协会。
BACKGROUND. It is known that 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is effective in the early detection of residual/recurrent nasopharyngeal carcinomas (NPC). To compare FDG-PET with the conventional magnetic resonance imaging (MRI) for the detection of residual/recurrent NPC, the authors studied 67 follow-up cases of patients with NPC using both FDG-PET and MRI.METHODS. From February 1997 to February 2001, 67 NPC patients (14 women, 53 men; age range, 16-67 years; mean age, 46.6 +/- 12.5 years) were recruited. Both FDG-PET and MRI of the head and neck area for each patient were performed at least 4 months (duration range, 4-70 months; mean, 14 +/- 13.5 months) after radiotherapy or radiotherapy with concurrent chemotherapy. The final diagnosis was confirmed by biopsy or clinical follow-up for at least 6 months.RESULTS. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of FDG-PET images were 100%, 93.4%, 95.5%, 87.5%, and 100%, respectively. In contrast, the sensitivity, specificity, accuracy, PPV, and NPV of the MRI scans were 61.9%, 43.5%, 49.3%, 33.3%, and 70.0%, respectively.CONCLUSIONS. The results of the current study suggest that FDG-PET is much more effective than MRI in detecting residual/recurrent NPC. (C) 2003 American Cancer Society.