Separate pathways for antigen presentation by CD1 molecules
Separate pathways for antigen presentation by CD1 molecules
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DOI：
10.1016/s1074-7613(00)80148-x
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发表时间：
1999-12-01
期刊：
影响因子：
32.4
通讯作者：
Brenner, MB
中科院分区：
文献类型：
--
作者：
Sugita, M;Grant, EP;Brenner, MB
对相关细胞内区室进行采样的能力对于有效的抗原呈递是必要的。为了检测肽抗原，MHC I 类和 II 类分子对胞质和内体区室进行差异采样。 CD1 构成了脂质抗原呈递分子的另一个谱系。我们发现 CD1b 深入进入晚期内体区室，而 CD1a 被排除在这些区室之外，而是在早期内吞系统的回收途径中独立运输。此外，CD1b而非CD1a抗原呈递依赖于囊泡酸化。由于已知脂质和各种细菌的运输存在差异，要么深入内吞系统，要么沿着内吞体的循环路线，这些发现阐明了 CD1 脂质抗原呈递分子对内吞区室不同成分的有效监测。
The ability to sample relevant intracellular compartments is necessary for effective antigen presentation. To detect peptide antigens, MHC class I and II molecules differentially sample cytosolic and endosomal compartments. CD1 constitutes another lineage of lipid antigen-presenting molecules. We show that CD1b traffics deeply into late endosomal compartments, while CD1a is excluded from these compartments and instead traffics independently in the recycling pathway of the early endocytic system. Further, CD1b but not CD1a antigen presentation is dependent upon vesicular acidification. Since lipids and various bacteria are known to traffic differentially, either penetrating deeply into the endocytic system or following the route of recycling endosomes, these findings elucidate efficient monitoring of distinct components of the endocytic compartment by CD1 lipid antigen-presenting molecules.