Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males
Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males
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DOI：
10.1016/j.cca.2009.12.028
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发表时间：
2010-04-02
影响因子：
5
通讯作者：
Nonaka, Masahiko
中科院分区：
文献类型：
--
作者：
Matsunaga, Tetsuro;Gu, Ning;Nonaka, Masahiko
背景：雌激素对心血管系统的有益作用是由雌激素受体介导的。我们研究了雌激素受体α基因（ESR1）的PvuII和XbaI多态性和心脏自主神经功能之间的关联在日本males.Methods：我们研究了252名年轻健康男性的协会ESR1 PvuII和XbaI多态性和短期心率变异性（HRV）在仰卧休息和站立的位置。通过频域分析对HRV的极低频（VLF）、低频（LF）和高频（HF）分量进行量化。ESR1 PvuII C等位基因携带者平均血压（BP）较高，而XbaI GG基因型与舒张压和平均血压较高，但HR较低显著相关。ESR1单倍型2携带者（PvuII C和XbaI A）等位基因具有较高的收缩压和平均血压，较低的HRV频谱功率（总功率、VLF、LF和HF分量）。结论：ESR1 PvuII和XbaI单倍型与血压变化和心脏自主神经活动的减少在年轻的日本男性，这可能是未来的心血管疾病的病理发作的前兆。(C)2010 Elsevier BV保留所有权利。
Background: Estrogens exert beneficial effects on the cardiovascular system that are mediated by estrogen receptors. We examined the association between the estrogen receptor alpha gene (ESR1) PvuII and XbaI polymorphisms and cardiac autonomic nervous function in Japanese males.Methods: We examined 252 young healthy males for association of ESR1 PvuII and XbaI polymorphisms and short-term heart rate variability (HRV) during supine rest and in a standing position. The very low frequency (VLF), low frequency (LF), and high frequency (HF) components of HRV were quantified by frequency domain analysis.Results: Carriers of the ESR1 PvuII C allele had higher mean blood pressure (BP), while the XbaI GG genotype was significantly associated with higher diastolic and mean BP, but lower HR. In the haplotype analysis, carriers of the ESR1 haplotype 2 (PvuII C and XbaI A) allele had a higher systolic and mean BP, and lower HRV spectral powers (total power, VLF, LF, and HF components) in a supine rest compared with those of non-carriers.Conclusions: The ESR1 PvuII and XbaI haplotype is associated with BP variation and the reduction in cardiac autonomic nervous activity in young Japanese males, which may be precursors of future pathological episodes of cardiovascular diseases. (C) 2010 Elsevier B.V. All rights reserved.