Executive functions in young males fragile X syndrome in comparison to mental age-matched with controls: Baseline findings from a longitudinal study
Executive functions in young males fragile X syndrome in comparison to mental age-matched with controls: Baseline findings from a longitudinal study
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DOI：
10.1037/0894-4105.22.1.36
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发表时间：
2008-01-01
期刊：
影响因子：
2.4
通讯作者：
Bailey, Donald B., Jr.
中科院分区：
文献类型：
--
作者：
Hooper, Stephen R.;Hatton, Deborah;Bailey, Donald B., Jr.
研究人员将54名7至13岁的脆性X染色体综合征（FXS）男孩与一组智力年龄（MA）和种族在执行功能（EF）多项指标上匹配的正常发育男孩的表现进行了比较。患有FXS的男孩完成EF测试的能力各不相同，只有25.9%的男孩能够完成集移任务，94.4%的男孩能够完成单词广度记忆任务。与对照组相比，在MA和母亲教育的控制下，FXS男孩在抑制、工作记忆、认知灵活性/设置转移和计划方面表现出显著的缺陷。各组处理速度无显著差异。心理年龄显著影响两组在工作记忆、场景转移、计划和处理速度任务上的表现。在FXS男孩中，MA显著预测工作记忆和集合转移任务的表现。我们的研究结果表明，患有FXS的男孩的EF缺陷不仅仅是由于发育迟缓，而是一种真正的神经认知缺陷。
The performance of 54 boys with fragile X syndrome (FXS), ages 7 to 13 years, was compared to that of a group of typically developing boys who were matched on mental age (MA) and ethnicity across multiple measures of executive function (EF). Boys with FXS varied in their ability to complete EF measures, with only 25.9% being able to complete a set-shifting task and 94.4% being able to complete a memory for word span task. When compared to the control group, and controlling for MA and maternal education, boys with FXS showed significant deficits in inhibition, working memory, cognitive flexibility/set-shifting, and planning. No group differences were observed in processing speed. Mental age significantly impacted performance on working memory, set-shifting, planning, and processing speed tasks for both groups. In boys with FXS, MA significantly predicted performance on working memory and set-shifting tasks. Our findings suggest that deficits in EF in boys with FXS are not solely attributable to developmental delays but, rather, present as a true array of neurocognitive deficits.