Directed meta-Selective Bromination of Arenes with Ruthenium Catalysts.
Directed meta-Selective Bromination of Arenes with Ruthenium Catalysts.
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DOI：
10.1002/anie.201507100
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发表时间：
2015-12
影响因子：
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通讯作者：
Qingzhen Yu;Le'an Hu;Yue Wang;Shasha Zheng;Jianhui Huang
中科院分区：
文献类型：
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作者：
Qingzhen Yu;Le'an Hu;Yue Wang;Shasha Zheng;Jianhui Huang
开发了一种Ru催化的带有吡啶基、嘧啶基和吡唑基导向基团的芳烃的直接C-H活化/偏溴化反应。已经合成了一系列溴代芳基吡啶和嘧啶，并且还证明了许多代表性官能化芳烃的进一步偶联反应。初步机理研究表明，当使用 NBS 作为溴源时，该反应可能通过自由基介导的溴化进行。这种类型的转化为金属的自由基非自身功能化开辟了新的方向，未来 C-H 活化的发展将允许芳香系统的远程功能化。
A Ru-catalyzed direct CH activation/meta-bromination of arenes bearing pyridyl, pyrimidyl, and pyrazolyl directing groups has been developed. A series of bromo aryl pyridines and pyrimidines have been synthesized, and further coupling reactions have also been demonstrated for a number of representative functionalized arenes. Preliminary mechanistic studies have revealed that this reaction may proceed through radical-mediated bromination when NBS is utilized as the bromine source. This type of transformation has opened up a new direction for the radical non-ipso functionalization of metal with regard to future CH activation development that would allow the remote functionalization of aromatic systems.